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Titolo:
Biological basket weaving: Formation and function of clathrin-coated vesicles
Autore:
Brodsky, FM; Chen, CY; Knuehl, C; Towler, MC; Wakeham, DE;
Indirizzi:
Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA USA UnivCalif San Francisco San Francisco CA USA hem, San Francisco, CA USA Univ Calif San Francisco, GW Hooper Fdn, Dept Microbiol & Immunol, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA nol, San Francisco, CA USA
Titolo Testata:
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
, volume: 17, anno: 2001,
pagine: 517 - 568
SICI:
1081-0706(2001)17:<517:BBWFAF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-MEDIATED ENDOCYTOSIS; GROWTH-FACTOR RECEPTOR; TRANS-GOLGI NETWORK; POLARIZED EPITHELIAL-CELLS; ADP-RIBOSYLATION FACTOR; REGULATED SECRETORY PATHWAY; PLECKSTRIN HOMOLOGY DOMAINS; PROTEIN SORTING PATHWAYS; DEEP-ETCH VISUALIZATION; SHOCK COGNATE PROTEIN;
Keywords:
adaptor; endocytosis; secretion; cytoskeleton; sorting;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
305
Recensione:
Indirizzi per estratti:
Indirizzo: Brodsky, FM Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 94143 USA
Citazione:
F.M. Brodsky et al., "Biological basket weaving: Formation and function of clathrin-coated vesicles", ANN R C DEV, 17, 2001, pp. 517-568

Abstract

There has recently been considerable progress in understanding the regulation of clathrin-coated vesicle (CCV) formation and function. These advancesare due to the determination of the structure of a number of CCV coat components at molecular resolution and the identification of novel regulatory proteins that control CCV formation in the cell. In addition, pathways of (a) phosphorylation, (b) receptor signaling, and (c) lipid modification that influence CCV formation, as well as the interaction between the cytoskeleton and CCV transport pathways are becoming better defined. It is evident that although clathrin coat assembly drives CCV formation, this fundamental reaction is modified by different regulatory proteins, depending on where CCVs are forming in the cell. This regulatory difference likely reflects the distinct biological roles of CCVs at the plasma membrane and trans-Golgi network, as well as the distinct properties of these membranes themselves. Tissue-specific functions of CCVs require even more-specialized regulation anddefects in these pathways can now be correlated with human diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:45:30