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Titolo:
How matrix metalloproteinases regulate cell behavior
Autore:
Sternlicht, MD; Werb, Z;
Indirizzi:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
, volume: 17, anno: 2001,
pagine: 463 - 516
SICI:
1081-0706(2001)17:<463:HMMRCB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN TISSUE INHIBITOR; HUMAN NEUTROPHIL COLLAGENASE; ABDOMINAL AORTIC-ANEURYSMS; HERNIATED DISC RESORPTION; ENDOTHELIAL GROWTH-FACTOR; SORSBYS-FUNDUS-DYSTROPHY; GELATINASE-B DEFICIENCY; TIMP-1 TRANSGENIC MICE; NECROSIS-FACTOR-ALPHA; IN-VIVO;
Keywords:
proteinases; tissue inhibitors of metalloproteinases; extracellular matrix; proteolytic signaling;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
230
Recensione:
Indirizzi per estratti:
Indirizzo: Sternlicht, MD Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 43 USA
Citazione:
M.D. Sternlicht e Z. Werb, "How matrix metalloproteinases regulate cell behavior", ANN R C DEV, 17, 2001, pp. 463-516

Abstract

The matrix metalloproteinases (MMPs) constitute a multigene family of over25 secreted and cell surface enzymes that process or degrade numerous pericellular substrates. Their targets include other proteinases, proteinase inhibitors, clotting factors, chemotactic molecules, latent growth factors, growth factor-binding proteins, cell surface receptors, cell-cell adhesion molecules, and virtually all structural extracellular matrix proteins. Thus MMPs are able to regulate many biologic processes and are closely regulatedthemselves. We review recent advances that help to explain how MMPs work, how they are controlled, and how they influence biologic behavior. These advances shed light on how the structure and function of the MMPs are relatedand on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled. MMPs participate in numerous normal and abnormal processes, and there are new insights into the key substrates and mechanisms responsible for regulating some of these processes in vivo. Our knowledge in the field of MMP biology is rapidly expanding, yet we still do not fully understand how these enzymes regulate most processes of development, homeostasis, and disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:09:42