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Titolo:
Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
Autore:
Weissman, IL; Anderson, DJ; Gage, F;
Indirizzi:
Stanford Univ, Sch Med, Beckman Ctr B257, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 kman Ctr B257, Stanford, CA 94305 USA CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA
Titolo Testata:
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
, volume: 17, anno: 2001,
pagine: 387 - 403
SICI:
1081-0706(2001)17:<387:SAPCOP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN NEURAL CREST; CENTRAL-NERVOUS-SYSTEM; COMMON MYELOID PROGENITOR; MINIMAL RESIDUAL DISEASE; FIBROBLAST GROWTH-FACTOR; BONE-MARROW CELLS; ADULT-MOUSE BRAIN; IN-VIVO; MYELOGENOUS LEUKEMIA; HIPPOCAMPAL-NEURONS;
Keywords:
stem cells; progenitors; multipotent; transdifferentiation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Weissman, IL Stanford Univ, Sch Med, Beckman Ctr B257, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 , Stanford, CA 94305 USA
Citazione:
I.L. Weissman et al., "Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations", ANN R C DEV, 17, 2001, pp. 387-403

Abstract

Multipotent stem cells are clonal cells that self-renew as well as differentiate to regenerate adult tissues. Whereas stem cells and their fates are known by unique genetic marker Studies, the fate and function of these cells are best studied by their prospective isolation. This review is about theproperties of various highly purified tissue-specific multipotent stem cells and purified oligolineage progenitors. We contend that unless the stem or progenitor cells in question have been purified to near homogeneity, one cannot know whether their generation of expected (or unexpected) progeny isa property of a known cell type. It is interesting that in the hematopoietic system the only long-term self-renewing cells in the stem and progenitors pool are the hematopoietic stem cells. This fact is discussed in the context of normal and leukemic hematopoiesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:01:41