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Titolo:
Salmonella interactions with host cells: Type III secretion at work
Autore:
Galan, JE;
Indirizzi:
Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA Yale Univ New Haven CT USA 06536 al Pathogenesis, New Haven, CT 06536 USA
Titolo Testata:
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
, volume: 17, anno: 2001,
pagine: 53 - 86
SICI:
1081-0706(2001)17:<53:SIWHCT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYPHIMURIUM INVASION GENES; ENTERICA SEROTYPE TYPHIMURIUM; INTESTINAL EPITHELIAL-CELLS; NUCLEOTIDE EXCHANGE FACTOR; PATHOGENICITY ISLAND 2; ACTIN-BINDING PROTEIN; BACTERIAL INVASION; NUCLEAR RESPONSES; MOLECULAR CHARACTERIZATION; SUPRAMOLECULAR STRUCTURE;
Keywords:
bacterial pathogenesis; protein secretion; actin cytoskeleton; Rho GTPases; vesicular trafficking;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
134
Recensione:
Indirizzi per estratti:
Indirizzo: Galan, JE Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, 333 Cedar St, New Haven, CT 06536 USA Yale Univ 333 Cedar St New Haven CT USA 06536 aven, CT 06536 USA
Citazione:
J.E. Galan, "Salmonella interactions with host cells: Type III secretion at work", ANN R C DEV, 17, 2001, pp. 53-86

Abstract

The bacterial pathogen Salmonella enterica has evolved a very sophisticated functional interface with its vertebrate hosts. At the center of this interface is a specialized organelle, the type III secretion system, that directs the translocation of bacterial proteins into the host cell. Salmonella spp. encode two such systems that deliver a remark-able array of bacterial proteins capable of modulating a variety of cellular functions, including actin cytoskeleton dynamics, nuclear responses, and endocytic trafficking. Many of these bacterial proteins operate by faithful mimicry of host proteins, in some cases representing the result of extensive molecular tinkering and convergent evolution. The coordinated action of these type III secreted proteins secures the replication and survival of the bacteria avoiding overt damage to the host. The study of this remarkable pathogen is not only illuminating general paradigms in microbial pathogenesis but is also providingvaluable insight into host cell functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:46:33