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Titolo:
Thrombospondins: Multifunctional regulators of cell interactions
Autore:
Adams, JC;
Indirizzi:
Univ Coll London, MRC, Mol Cell Biol Lab, London WC1E 6BT, England Univ Coll London London England WC1E 6BT l Lab, London WC1E 6BT, England Univ Coll London, Dept Biochem & Mol Biol, London WC1E 6BT, England Univ Coll London London England WC1E 6BT Biol, London WC1E 6BT, England
Titolo Testata:
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
, volume: 17, anno: 2001,
pagine: 25 - 51
SICI:
1081-0706(2001)17:<25:TMROCI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
OLIGOMERIC MATRIX PROTEIN; SMOOTH-MUSCLE CELLS; INTEGRIN-ASSOCIATED PROTEIN; HEPARIN-BINDING PEPTIDES; LOW-DENSITY-LIPOPROTEIN; 5-STRANDED COILED-COIL; FOCAL ADHESION KINASE; HAMSTER OVARY CELLS; RAT CAROTID-ARTERY; GROWTH-FACTOR-BETA;
Keywords:
extracellular matrix; adhesion; cytoskeleton; signaling; angiogenesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
172
Recensione:
Indirizzi per estratti:
Indirizzo: Adams, JC Univ Coll London, MRC, Mol Cell Biol Lab, Gower St, London WC1E 6BT, England Univ Coll London Gower St London England WC1E 6BT 6BT, England
Citazione:
J.C. Adams, "Thrombospondins: Multifunctional regulators of cell interactions", ANN R C DEV, 17, 2001, pp. 25-51

Abstract

dThrombospondins are secreted, multidomain macromolecules that act as regulators of cell interactions in vertebrates. Gene knockout mice constructed for two members of this family demonstrate roles in the organization and homeostasis of multiple tissues, with particularly significant activities in the regulation of angiogenesis. This review discusses the functions of thrombospondins with regard to their cellular mechanisms of action and highlights recent advances in understanding how multifactorial molecular interactions, at the cell surface and within extracellular matrix, produce cell-type-specific effects on cell behavior and the organization of matrix and tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:52:01