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Titolo:
The zona pellucida-induced acrosome reaction of human spermatozoa involvesextracellular signal-regulated kinase activation
Autore:
du Plessis, SS; Page, C; Franke, DR;
Indirizzi:
Univ Stellenbosch, Dept Med Physiol & Biochem, ZA-7505 Tygerberg, South Africa Univ Stellenbosch Tygerberg South Africa ZA-7505 Tygerberg, South Africa Univ Stellenbosch, Tygerberg Hosp, Dept Obstet & Gynaecol, Tygerberg, South Africa Univ Stellenbosch Tygerberg South Africa aecol, Tygerberg, South Africa
Titolo Testata:
ANDROLOGIA
fascicolo: 6, volume: 33, anno: 2001,
pagine: 337 - 342
SICI:
0303-4569(200111)33:6<337:TZPARO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE PHOSPHORYLATION; MICROTUBULE-ASSOCIATED PROTEIN-2; HUMAN-SPERM; INVITRO FERTILIZATION; CAPACITATION; BINDING; STIMULATION; INDUCTION; MEMBRANE; CELLS;
Keywords:
acrosome; extracellular signal-regulated kinase (ERK) spermatozoa; zona pellucida;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: du Plessis, SS Univ Stellenbosch, Dept Med Physiol & Biochem, POB 19063, ZA-7505 Tygerberg, South Africa Univ Stellenbosch POB 19063 Tygerberg SouthAfrica ZA-7505
Citazione:
S.S. du Plessis et al., "The zona pellucida-induced acrosome reaction of human spermatozoa involvesextracellular signal-regulated kinase activation", ANDROLOGIA, 33(6), 2001, pp. 337-342

Abstract

Extracellular signal-regulated kinases (ERKs), belonging to the family of mitogen-activated protein kinases (MAPKs), are cytoplasmic and nuclear serine/threonine kinases involved in the signal transduction of several extracellular effectors. Recent evidence indicates the presence of p21 Ras and thephosphorylation of ERK1 and ERK2, suggesting the occurrence of the Ras/ERKcascade in mammalian spermatozoa. The present article describes the biological role of ERK during the acrosome reaction of human spermatozoa on stimulation with zona pellucida (ZP). The mitogen-activated protein-kinase inhibitor PD098059 was used as a pharmacological tool to study the involvement of extracellular signal-regulated kinases in the induction of the acrosome reaction in human spermatozoa. This compound significantly inhibited the acrosome reaction induced by both ZP and the calcium ionophore A23187. These results suggest that ERKs are involved in the signal transduction pathway through which ZP stimulation works during the process of fertilization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 15:18:44