Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The role of immunoglobulin E in allergy and asthma
Autore:
Platts-Mills, TAE;
Indirizzi:
Univ Virginia, Med Ctr, Div Allergy & Immunol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 8, volume: 164, anno: 2001, supplemento:, S
pagine: S1 - S5
SICI:
1073-449X(20011015)164:8<S1:TROIEI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOUSE-DUST MITE; SKIN-TEST REACTIVITY; FC-EPSILON-RI; MAST-CELLS; SERUM IGE; AIRWAY RESPONSIVENESS; ATOPIC-DERMATITIS; CHILDHOOD ASTHMA; EARLY EXPOSURE; CHILDREN;
Keywords:
pathophysiology; asthma; allergy; IgE; allergic cascade;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Platts-Mills, TAE Univ Virginia, Med Ctr, Div Allergy & Immunol, Box 225, Charlottesville, VA 22908 USA Univ Virginia Box 225 Charlottesville VA USA 22908 8 USA
Citazione:
T.A.E. Platts-Mills, "The role of immunoglobulin E in allergy and asthma", AM J R CRIT, 164(8), 2001, pp. S1-S5

Abstract

it has been nearly a century since the first suggestion that a soluble factor in plasma or serum might be responsible for the symptoms of allergic disease and asthma, and more than 30 yr since immunoglobulin E (IgE) was identified as the key molecule in mediating what are now described as type 1 hypersensitivity reactions (allergic asthma, allergic rhinitis, food allergy,atopic dermatitis, some forms of drug allergy, and insect sting allergy). Since that time, many of the details of the inflammatory cascade underlyingallergy and asthma have been elucidated, and IgE is now known to play a key upstream role. The goals of this report are to review the cellular and molecular events set in motion by IgE and to examine the evidence for its participation in both the immediate allergic response and the late-phase or chronic inflammatory response in the skin and lungs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:34:52