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Titolo:
Cortisol feedback during the HPA quiescent period in patients with major depression
Autore:
Posener, JA; DeBattista, C; Williams, GH; Schatzberg, AF;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Metropolitan St Louis Psychiat Ctr, St Louis, MO USA Metropolitan St LouisPsychiat Ctr St Louis MO USA Ctr, St Louis, MO USA Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA Harvard Univ, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115Harvard Univ, Boston, MA 02115 USA Brigham & Womens Hosp, Div Endocrinol & Hypertens, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Hypertens, Boston, MA 02115 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 12, volume: 158, anno: 2001,
pagine: 2083 - 2085
SICI:
0002-953X(200112)158:12<2083:CFDTHQ>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTH-SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Posener, JA Washington Univ, Sch Med, Dept Psychiat, 660 S Euclid Ave,Box 8134, St Louis, MO 63110 USA Washington Univ 660 S Euclid Ave,Box 8134 St Louis MO USA 63110
Citazione:
J.A. Posener et al., "Cortisol feedback during the HPA quiescent period in patients with major depression", AM J PSYCHI, 158(12), 2001, pp. 2083-2085

Abstract

Objective: The authors tested the hypothesis that patients with major depression have a defect in the mechanism by which cortisol exerts negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis during the HPA axis quiescent period. Method: Twenty-nine patients with major depression and 25 healthy comparison subjects were randomly assigned to administration of 15 mg cortisol or placebo infused over 2 hours beginning at 7:00 p.m. Cortisol and ACTH levelswere measured at baseline and every 30 minutes from 7:30 p.m. to 11:00 p.m. Results: Differences between the patients and the comparison subjects in the ACTH response to the cortisol infusion, relative to the ACTH response toplacebo, were not found. Conclusions: The results provide some evidence that patients with major depression do not have an abnormality of cortisol feedback during the HPA axis quiescent period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:02:03