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Titolo:
Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression
Autore:
Whyte, EM; Pollock, BG; Wagner, WR; Mulsant, BH; Ferrell, RE; Mazumdar, S; Reynolds, CF;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 sychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 pt Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Neurol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 n Genet, Pittsburgh, PA 15261 USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Biostat, Pittsburgh, PA 15261 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 12, volume: 158, anno: 2001,
pagine: 2074 - 2076
SICI:
0002-953X(200112)158:12<2074:IOSPRP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; LATE-LIFE DEPRESSION; ALLELIC VARIATION; MAJOR DEPRESSION; PAROXETINE; NORTRIPTYLINE; REACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Whyte, EM Rm 886-Bm3811 Ohara St, Pittsburgh, PA 15213 USA Rm 886-Bm3811 Ohara St Pittsburgh PA USA 15213 gh, PA 15213 USA
Citazione:
E.M. Whyte et al., "Influence of serotonin-transporter-linked promoter region polymorphism on platelet activation in geriatric depression", AM J PSYCHI, 158(12), 2001, pp. 2074-2076

Abstract

Objective: Depression has been associated with increased platelet activation. Variations in the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism may influence the degree of activation. The authors examined the association among depression, platelet activation, and 5-HTTLPR genotype. Method: Elderly subjects with (N=61) and without (N=12) major depression were assessed for cognitive impairment, cardiovascular disease, and two indices of platelet activation. The depressed subjects were genotyped for the 5-HTTLPR polymorphism. Results: The depressed subjects were older, were more cognitively impaired, and had higher platelet factor 4 and beta -thromboglobulin levels; cardiovascular disease was minimal in both groups. In the depressed group, subjects with the 5-HTTLPR I/I genotype had significantly higher platelet factor 4 and beta -thromboglobulin levels. Conclusions: Platelet activation is increased in elderly depressed patients, especially those with the 5-HTTLPR I/I genotype. This finding suggests how genetic differences may influence cardiovascular mortality in depressed patients with ischemic heart disease.

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Documento generato il 29/03/20 alle ore 08:20:27