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Titolo:
Low level of brain dopamine D-2 receptors in methamphetamine abusers: Association with metabolism in the orbitofrontal cortex
Autore:
Volkow, ND; Chang, L; Wang, GJ; Fowler, JS; Ding, YS; Sedler, M; Logan, J; Franceschi, D; Gatley, J; Hitzemann, R; Gifford, A; Wong, C; Pappas, N;
Indirizzi:
Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 ab, Dept Chem, Upton, NY 11973 USA SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 12, volume: 158, anno: 2001,
pagine: 2015 - 2021
SICI:
0002-953X(200112)158:12<2015:LLOBDD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; POSITRON-EMISSION-TOMOGRAPHY; CONDITIONED PLACE PREFERENCE; DEPENDENT SUBJECTS; PREFRONTAL CORTEX; C-11 RACLOPRIDE; COCAINE ABUSERS; BLOOD-FLOW; DRUG; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Volkow, ND Brookhaven Natl Lab, Dept Med, BSA,POB 5000, Upton, NY 11973 USA Brookhaven Natl Lab BSA,POB 5000 Upton NY USA 11973 Y 11973 USA
Citazione:
N.D. Volkow et al., "Low level of brain dopamine D-2 receptors in methamphetamine abusers: Association with metabolism in the orbitofrontal cortex", AM J PSYCHI, 158(12), 2001, pp. 2015-2021

Abstract

objective: The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine D-2 receptors. In cocaine abusers, low levels of D-2 receptors are associated with a lower level ofmetabolism in the orbitofrontal cortex. Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers. Method: Fifteen methamphetamine abusers and 20 non-drug-abusing comparisonsubjects were studied with positron emission tomography (PET) and [C-11]raclopride to assess the availability of dopamine D-2 receptors and with [F-18]fluorodeoxyglucose to assess regional brain glucose metabolism, a marker of brain function. Results: Methamphetamine abusers had a significantly lower level of D-2 receptor availability than comparison subjects (a difference of 16% in the caudate and 10% in the putamen). D-2 receptor availability was associated with metabolic rate in the orbitofrontal cortex in abusers and in comparison subjects. Conclusions: Lower levels of dopamine D-2 receptor availability have been previously reported in cocaine abusers, alcoholics, and heroine abusers. This study extends this finding to methamphetamine abusers. The association between level of dopamine D-2 receptors and metabolism in the orbitofrontal cortex in methamphetamine abusers, which replicates previous findings in cocaine abusers, suggests that D-2 receptor-mediated dysregulation of the orbitofrontal cortex could underlie a common mechanism for loss of control andcompulsive drug intake in drug-addicted subjects.

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Documento generato il 29/03/20 alle ore 15:08:48