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Titolo:
Rapid response of identified resident endoneurial macrophages to nerve injury
Autore:
Mueller, M; Wacker, K; Ringelstein, EB; Hickey, WF; Imai, Y; Kiefer, R;
Indirizzi:
Univ Klinikum Munster, Dept Neurol, D-48129 Munster, Germany Univ KlinikumMunster Munster Germany D-48129 , D-48129 Munster, Germany Natl Inst Neurosci, Dept Neurochem, Tokyo, Japan Natl Inst Neurosci Tokyo Japan t Neurosci, Dept Neurochem, Tokyo, Japan Dartmouth Hitchcock Med Ctr, Dartmouth Med Sch, Dept Pathol, Lebanon, NH USA Dartmouth Hitchcock Med Ctr Lebanon NH USA Dept Pathol, Lebanon, NH USA
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 6, volume: 159, anno: 2001,
pagine: 2187 - 2197
SICI:
0002-9440(200112)159:6<2187:RROIRE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARROW-DERIVED ELEMENTS; WALLERIAN DEGENERATION; PERIPHERAL-NERVES; MYELIN PHAGOCYTOSIS; MICROGLIAL CELLS; SCHWANN-CELLS; SYSTEM; ANTIGEN; RECRUITMENT; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kiefer, R Univ Klinikum Munster, Dept Neurol, Albert Schweitzer Str 33, D-48129 Munster, Germany Univ Klinikum Munster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
M. Mueller et al., "Rapid response of identified resident endoneurial macrophages to nerve injury", AM J PATH, 159(6), 2001, pp. 2187-2197

Abstract

Macrophages play a central role in the pathogenesis of peripheral neuropathy but the role of resident endoneurial macrophages is undefined because nodiscriminating markers exist to distinguish them from infiltrating hematogenous; macrophages. We identified and characterized resident endoneurial macrophages during Wallerian degeneration in radiation bone marrow chimeric rats created by transplanting wild-type Lewis rat bone marrow into irradiated TK-tsa transgenic Lewis rats. In such animals, resident cells carry the transgene, whereas hematogenous cells do not. As early as 2 days after sciatic nerve crush and before the influx of hematogenous macrophages, resident transgene-positive endoneurial macrophages underwent morphological and immunophenotypic signs of activation. At the same time, resident macrophages phagocytosing myelin were found, and proliferation was detected by bromodeoxyuridine incorporation. Continuous bromodeoxyuridine feeding revealed that resident endoneurial macrophages sequentially retracted their processes, proliferated, and expressed the ED1 antigen, rendering them morphologically indistinguishable from hematogenous macrophages. Resident endoneurial macrophages thus play an early and active role in the cellular events after nerve lesion before hematogenous macrophages, enter the nerve. They may thus be critically involved in the pathogenesis of peripheral neuropathy particularly at early stages of the disease and may act as sensors of pathology much like their central nervous system counterparts, the microglial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:49:22