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Titolo:
Association between three functional polymorphisms of dopamine D2 receptorgene and tardive dyskinesia in schizophrenia
Autore:
Hori, H; Ohmori, O; Shinkai, T; Kojima, H; Nakamura, J;
Indirizzi:
Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 8, volume: 105, anno: 2001,
pagine: 774 - 778
SICI:
0148-7299(200112)105:8<774:ABTFPO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC TREATMENT; HEALTHY-VOLUNTEERS; A1 ALLELE; PREVALENCE; SUSCEPTIBILITY; VARIANT;
Keywords:
tardive dyskinesia; dopamine D2 receptor gene; polymorphism; association study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Hori, H Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 pan
Citazione:
H. Hori et al., "Association between three functional polymorphisms of dopamine D2 receptorgene and tardive dyskinesia in schizophrenia", AM J MED G, 105(8), 2001, pp. 774-778

Abstract

The dopamine D2 receptor (DRD2) gene is considered one of the candidate genes contributing to the development of tardive dyskinesia (TD). In the present study, we investigated the genetic association between three functionalpolymorphisms (Ser311Cys, -141C Ins/Del and TaqI A) in the DRD2 gene and TD (200 patients with schizophrenia: 44 with TD and 156 without TD). No significant difference in the allelic and genotypic distribution between patients with TD and those without TD was observed. However, we found a slightly significant association between the -141C Ins/Del polymorphism and the total Abnormal Involuntary Movement Scale (AIMS) score (P = 0.037). The significant association between the -141C Ins/Del polymorphism. and the total AIMSscore did not remain after the regression analysis was taken into account (P=0.14). Our results suggest that that three functional polymorphisms in DRD2 may not play a major role in the occurrence of TD. (C) 2001 Wiley-Liss,Inc.

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Documento generato il 25/01/20 alle ore 15:45:55