Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Alzheimer disease is not associated with polymorphisms in the angiotensinogen and renin genes
Autore:
Taylor, A; Ezquerra, M; Bagri, G; Yip, A; Goumidi, L; Cottel, D; Easton, D; Evans, JG; Xuereb, J; Cairns, NJ; Amouyel, P; Chartier-Harlin, MC; Brayne, C; Rubinsztein, DC;
Indirizzi:
Addenbrookes Hosp, Cambridge Inst Med Res, Wellcome Trust Ctr Mol Mechanisms Dis, Dept Med Genet, Cambridge CB2 2XY, England Addenbrookes Hosp Cambridge England CB2 2XY , Cambridge CB2 2XY, England Inst Pasteur, INSERM 508, F-59019 Lille, France Inst Pasteur Lille France F-59019 eur, INSERM 508, F-59019 Lille, France Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, CRC Genet Epidemiol Unit, Cambridge, England Univ Cambridge Cambridge England net Epidemiol Unit, Cambridge, England Radcliffe Infirm, Dept Clin Geratol, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE Geratol, Oxford OX2 6HE, England Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Cambridge CB2 2QQ, EnglandUniv Cambridge Cambridge England CB2 2QQ hol, Cambridge CB2 2QQ, England Univ London Kings Coll, Inst Psychiat, Dept Neuropathol, Brain Bank, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 8, volume: 105, anno: 2001,
pagine: 761 - 764
SICI:
0148-7299(200112)105:8<761:ADINAW>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; HYPERTENSION; DEMENTIA; SUSCEPTIBILITY; METAANALYSIS; ACE;
Keywords:
Alzheimer disease; dementia; renin; angiotensinogen; MRC CFAS study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Rubinsztein, DC Addenbrookes Hosp, Cambridge Inst Med Res, Wellcome Trust Ctr Mol Mechanisms Dis, Dept Med Genet, Wellcome-MRC Bldg,Hills Rd, Cambridge CB2 2XY, England Addenbrookes Hosp Wellcome-MRC Bldg,Hills Rd CambridgeEngland CB2 2XY
Citazione:
A. Taylor et al., "Alzheimer disease is not associated with polymorphisms in the angiotensinogen and renin genes", AM J MED G, 105(8), 2001, pp. 761-764

Abstract

Hypertension has been implicated as a risk factor for Alzheimer disease (AD) and dementia in epidemiological studies of humans. It is thus possible that there are common genetic determinants for hypertension and AD. Epidemiological, clinical, and experimental data suggest that the reninangiotensin-aldosterone system is a critical regulator of blood pressure. The presence of an MboI site in an RFLP in the renin gene and the Thr at the Met/Thr polymorphism at codon 235 (M235T) of the angiotensinogen gene have been reported to be associated with hypertension. These variants were studied in autopsy-confirmed AD cases and matched controls from the U.K. While no association was detected with the renin polymorphism, a weak deleterious effect was observed in cases homozygous for the angiotensinogen Thr allele. However, this association was not observed in a French cohort of clinically diagnosedAD cases and controls, suggesting that the initial observation was a type I error. Thus, these polymorphisms are unlikely to be associated with AD risk. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 02:34:01