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Titolo:
No association of the dopamine transporter gene 3 ' VNTR polymorphism withADHD subtypes in a population sample of twins
Autore:
Todd, RD; Jong, YJI; Lobos, EA; Reich, W; Heath, AC; Neuman, RJ;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 8, volume: 105, anno: 2001,
pagine: 745 - 748
SICI:
0148-7299(200112)105:8<745:NAOTDT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; CHILDHOOD DISORDERS; LATENT CLASS; FAMILY; PERSPECTIVE;
Keywords:
dopamine transporter; ADHD; latent class analysis; genetic association; transmission disequilibrium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Todd, RD Washington Univ, Sch Med, Dept Psychiat, 660 S Euclid Ave,Campus Box 8134,St Louis, MO 63110 USA Washington Univ 660 S Euclid Ave,Campus Box8134 St Louis MO USA 63110
Citazione:
R.D. Todd et al., "No association of the dopamine transporter gene 3 ' VNTR polymorphism withADHD subtypes in a population sample of twins", AM J MED G, 105(8), 2001, pp. 745-748

Abstract

Dopamine pathway genes have been the subject of a variety of studies testing the association of candidate genes and liability for attention-deficit hyperactivity disorder (ADHD). Due to the known effects of stimulant medications such as methylphenidate on the dopamine transporter, a variety of casecontrol and family-based transmission distortion genetic studies of ADHD have focused on DAT1 polymorphisms. The most widely reported positive finding has been with a variable number of tandem repeats (VNTR) polymorphism of unknown function in the 3' untranslated region of the DAT1 gene. In this report, we test for association of alleles of this polymorphism. with ADHD using population-derived samples of twins. We use the transmission disequilibrium test and ADHD subtypes defined by both DSM-IV and latent class criteria. We fail to demonstrate any significant association or trend for association of any of the VNTR alleles with any of the variously defined ADHD subtypes. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 11/07/20 alle ore 14:34:13