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Titolo:
Genetic covariation of neuroticism with monoamine oxidase activity and smoking
Autore:
Kirk, KM; Whitfield, JB; Pang, D; Heath, AC; Martin, NG;
Indirizzi:
Univ Queensland, Dept Psychiat, Brisbane, Qld 4029, Australia Univ Queensland Brisbane Qld Australia 4029 Brisbane, Qld 4029, Australia Queensland Inst Med Res, Genet Epidemiol Lab, Brisbane, Qld 4006, Australia Queensland Inst Med Res Brisbane Qld Australia 4006 , Qld 4006, Australia Royal Prince Alfred Hosp, Sydney, NSW, Australia Royal Prince Alfred HospSydney NSW Australia sp, Sydney, NSW, Australia Univ Sydney, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia2006 Sydney, Sydney, NSW 2006, Australia Washington Univ, Missouri Alcoholism Res Ctr, St Louis, MO 63130 USA Washington Univ St Louis MO USA 63130 ism Res Ctr, St Louis, MO 63130 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 8, volume: 105, anno: 2001,
pagine: 700 - 706
SICI:
0148-7299(200112)105:8<700:GCONWM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; ANXIETY-RELATED TRAITS; PERSONALITY-TRAITS; B ACTIVITY; PROMOTER POLYMORPHISM; GENERALIZED ANXIETY; ALCOHOL DEPENDENCE; PLATELET; ASSOCIATION; TWINS;
Keywords:
neuroticism; MAO activity; cigarette consumption; smoking; twins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Kirk, KM PO Royal Melbourne Hosp, Queensland Inst Med Res, Brisbane, Qld 4029, Australia PO Royal Melbourne Hosp Brisbane Qld Australia 4029 9, Australia
Citazione:
K.M. Kirk et al., "Genetic covariation of neuroticism with monoamine oxidase activity and smoking", AM J MED G, 105(8), 2001, pp. 700-706

Abstract

Variation in the personality trait of neuroticism is known to be affected by genetic influences, but despite a number of association studies, the genes involved have not yet been characterized. In a recent study of platelet monoamine oxidase in 1,551 twin subjects, we found a significant association between monoamine oxidase activity and scores on the Eysenck Personality Questionnaire neuroticism scale. Further analyses presented here indicate that both neuroticism and monoamine oxidase activity are associated with variation in smoking habits, and that adjusting for the effect of smoking strengthens the association between MAO and neuroticism. Analysis of the genetic and environmental sources of covariation between neuroticism, smoking, and monoamine oxidase activity show that approximately 8% of the genetic variance in neuroticism is due to the same additive genetic effects that contribute to variation in monoamine oxidase activity, suggesting that variation in neuroticism is associated in part with aspects of serotonin metabolism. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:18:52