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Titolo:
Treatment of deep vein thrombosis using low-molecular-weight heparins
Autore:
Groce, JB;
Titolo Testata:
AMERICAN JOURNAL OF MANAGED CARE
fascicolo: 17, volume: 7, anno: 2001, supplemento:, S
pagine: S510 - S523
SICI:
1088-0224(200111)7:17<S510:TODVTU>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS UNFRACTIONATED HEPARIN; DAILY SUBCUTANEOUS DALTEPARIN; VENOUS THROMBOSIS; PULMONARY-EMBOLISM; METAANALYSIS; FREQUENCY; TRIALS; HOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Groce, "Treatment of deep vein thrombosis using low-molecular-weight heparins", AM J M CARE, 7(17), 2001, pp. S510-S523

Abstract

Because it eliminates the need for intravenous infusions and lengthy hospitalizations, use of low-molecular-weight heparins (LMWHs) for the treatmentof deep vein thrombosis (DVT) can improve patient outcomes of safety and efficacy and reduce the cost of medical care. in a meta-analysis of randomized controlled trials involving more than 3500 patients, treatment with LMWHversus unfractionated heparin was associated with lower mortality, a lowerincidence of major bleeding episodes and thrombocytopenia, and an overall reduction of about 30% in morbidity from recurrent thromboembolism and bleeding. The metaanalysis also demonstrated cost savings of $1900 per patient for those treated with LMWH. More recent studies evaluating several LMWHs in both hospital and outpatient settings have shown that the drugs are more effective in reducing risk for recurrent events and complications than unfractionated heparin. The use of LMWHs for outpatient treatment of DVT has, of necessity, given rise to specific protocols, inclusion and exclusion criteria, follow-up procedures, and multidisciplinary approaches to outpatient management. These guidelines are reviewed here, as are special considerations for patients who are obese or who have renal insufficiency.

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Documento generato il 05/04/20 alle ore 04:00:23