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Titolo:
Influence of coronary thrombus on outcome of percutaneous coronary angioplasty in the current era (The Mayo Clinic experience)
Autore:
Singh, M; Berger, PB; Ting, HH; Rihal, CS; Wilson, SH; Lennon, RJ; Reeder, GS; Bresnahan, JF; Holmes, DR;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Biostat Sect, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Sect, Rochester, MN 55905 USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 10, volume: 88, anno: 2001,
pagine: 1091 - 1096
SICI:
0002-9149(20011115)88:10<1091:IOCTOO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; PILOT TRIAL; ABCIXIMAB; MULTICENTER; OCCLUSION; CLOSURE; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Holmes, DR Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 5 USA
Citazione:
M. Singh et al., "Influence of coronary thrombus on outcome of percutaneous coronary angioplasty in the current era (The Mayo Clinic experience)", AM J CARD, 88(10), 2001, pp. 1091-1096

Abstract

Earlier studies documented an increased risk of percutoneous coronary intervention (PCI) in patients with angiographic evidence of thrombus. With newer antiplatelet agents and stents, it is not known whether thrombus is a risk factor after PCI. This study examines whether outcome of PCI in patientswith thrombus has improved, and whether thrombus is associated with adverse outcome after PCI in the current era. This single-institution retrospective analysis of PCI in 7,184 patients was divided into 2 periods: group I, 1990 to 1995 (n=3,640), and group II, 1996 to 1999 (n=3,544). The groups were subdivided according to the presence or absence of angiographic thrombus before PCI. We compared the outcome of PCI for patients with and without thrombus in group II. A comparison was made in the 2 groups in patients with angiographic thrombus. Procedural success improved in group II compared with group I patients with thrombus (93% vs 88%, p<0.001). There was significant reduction in abrupt closure in the recent era in patients with thrombus (4% vs 7%, p=0.01). In group II, procedural success remained lower in patients with (93% vs 96%) than without thrombus (p<0.001). After adjusting for the significant univariate characteristics of group II patients, thrombus remained an independent predictor of Q-wave infarction (odds ratio 3.78; 95%confidence interval [CI], 1.8 to 8.0; p<0.0013) and the composite end point Of death, Q-wave infarction, and emergency bypass surgery (odds ratio 2.37; 95% CI 1.4 to 4.1; p=0.002). There was a trend toward increased in-hospital death among patients with thrombus (odds ratio 2.06; 95% CI 0.9 to 4.8;p=0.09). The 1-year outcome after successful PCI was similar for those with and without thrombus. Despite improvement in the outcome of patients withthrombus undergoing PCI in recent years, thrombus is still an independent predictor of adverse in-hospital outcomes after PCI. (C) 2001 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:33:08