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Titolo:
Importance of time to reperfusion on outcomes with primary coronary angioplasty for acute myocardial infarction (results from the Stent Primary Angioplasty in Myocardial Infarction Trial)
Autore:
Brodie, BR; Stone, GW; Morice, MC; Cox, DA; Garcia, E; Mattos, LA; Boura, J; ONeill, WW; Stuckey, TD; Milks, S; Lansky, AJ; Grines, CL;
Indirizzi:
Moses Cone Hosp, LeBauer Cardiovasc Res Fdn, Greensboro, NC USA Moses ConeHosp Greensboro NC USA Cardiovasc Res Fdn, Greensboro, NC USA Cardiovasc Res Fdn, New York, NY USA Cardiovasc Res Fdn New York NY USACardiovasc Res Fdn, New York, NY USA Inst Cardiovasc Paris Sud, Antony, France Inst Cardiovasc Paris Sud Antony France ovasc Paris Sud, Antony, France Mid Carolina Cardiol, Charlotte, NC USA Mid Carolina Cardiol Charlotte NCUSA arolina Cardiol, Charlotte, NC USA Hosp Gregorio Maranon, Madrid, Spain Hosp Gregorio Maranon Madrid SpainHosp Gregorio Maranon, Madrid, Spain Inst Dante Pazzanese Cardiol, Sao Paulo, Brazil Inst Dante Pazzanese Cardiol Sao Paulo Brazil ardiol, Sao Paulo, Brazil William Beaumont Hosp, Div Cardiol, Royal Oak, MI USA William Beaumont Hosp Royal Oak MI USA p, Div Cardiol, Royal Oak, MI USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 10, volume: 88, anno: 2001,
pagine: 1085 - 1090
SICI:
0002-9149(20011115)88:10<1085:IOTTRO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN-ACTIVATOR; THROMBOLYTIC THERAPY; SYMPTOM-ONSET; SALVAGE; MECHANISM; MORTALITY; SURVIVAL; DELAY; DEATH; SIZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Brodie, BR 520 N Elam Ave, Greensboro, NC 27403 USA 520 N Elam Ave Greensboro NC USA 27403 reensboro, NC 27403 USA
Citazione:
B.R. Brodie et al., "Importance of time to reperfusion on outcomes with primary coronary angioplasty for acute myocardial infarction (results from the Stent Primary Angioplasty in Myocardial Infarction Trial)", AM J CARD, 88(10), 2001, pp. 1085-1090

Abstract

The mortality benefit of thrombolytic therapy for acute myocardial infarction (AMI) is strongly dependent on time to treatment. Recent observations suggest that time to treatment may be less important with primary percutaneous transluminal coronary angioplasty (PTCA). Patients with AMI of < 12 hours duration, without cardiogenic shock, who were treated with primary PTCA from the Stent PAMI Trial (n=1,232) were evaluated to assess the effect of time to reperfusion on outcomes. Thrombolysis In Myocardial Infarction grade3 flow was achieved in a high proportion of patients regardless of time totreatment. Improvement in ejection fraction from baseline to 6 months was substantial with reperfusion at < 2 hours but was modest and relatively independent of time to reperfusion after 2 hours (<2 hours, 12.3% vs <greater than or equal to>2 hours, 4.2%, p=0.004). There were no differences in 1- or 6-month mortality by time to reperfusion (6-month mortality: <2 hours [5.5%], 2 to <4 hours [4.6%], 4 to <6 hours [4.5%], >6 hours [4.2%], p=0.97). There were also no differences in other clinical outcomes by time to reperfusion, except that reinfarction and infarct artery reocclusion at 6 months were more frequent with later reperfusion. The lack of correlation between time to treatment and mortality in patients without cardiogenic shock suggests that the survival benefit of primary PTCA may be related principally tofactors other than myocardial salvage. These data may also have implications regarding the triage of patients with AMI for primary PTCA. (C) 2001 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 18:56:14