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Titolo:
Palmitate oxidation in rat hepatocytes is inhibited by foetal calf serum
Autore:
Sleboda, J; Bremer, J; Horn, RS;
Indirizzi:
Univ Oslo, Inst Med Biochem, N-0317 Oslo, Norway Univ Oslo Oslo Norway N-0317 Oslo, Inst Med Biochem, N-0317 Oslo, Norway
Titolo Testata:
ACTA PHYSIOLOGICA SCANDINAVICA
fascicolo: 3, volume: 173, anno: 2001,
pagine: 267 - 274
SICI:
0001-6772(200111)173:3<267:POIRHI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARNITINE PALMITOYLTRANSFERASE-I; FATTY-ACID METABOLISM; MESSENGER-RNA ABUNDANCE; MALONYL-COA; LIVER MITOCHONDRIA; SENSITIVITY; FETAL; KETOGENESIS; TRANSITION; INSULIN;
Keywords:
carnitine palmitoyltransferase; fatty acid synthesis; fatty acid oxidation; foetal calf serum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Horn, RS Univ Oslo, Inst Med Biochem, POB 1112, N-0317 Oslo, Norway Univ Oslo POB 1112 Oslo Norway N-0317 1112, N-0317 Oslo, Norway
Citazione:
J. Sleboda et al., "Palmitate oxidation in rat hepatocytes is inhibited by foetal calf serum", ACT PHYSL S, 173(3), 2001, pp. 267-274

Abstract

The rate of oxidation of fatty acids in mammals is minimal prior to birth. In this study, we have shown that foetal calf serum (FCS) inhibits oxidation of palmitate while serum from newborn calves is almost without effect. Foetal calf serum was also found to increase fatty acid synthesis from acetate. Uptake of laurate in mitochondria is partially dependent upon the carnitine palmitoyltransferase (CPT) I/CPT II system, while octanoate transport occurs without its participation. Comparison of the effects of FCS or the oxidation of palmitate, laurate and octanoate supports the view that the observed actions of FCS result from regulation of CPT I activity, The materialin FCS that affects fatty acid metabolism has a molecular weight <3 kDa, as determined by dialysis and ultra-filtration studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 18:43:35