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Titolo:
Negligible ability of oxygen and peroxide ion activation by Al(III) ion isessential for Al(III)-induced neurodegeneration
Autore:
Nishida, Y;
Indirizzi:
Yamagata Univ, Fac Sci, Dept Chem, Yamagata 9908560, Japan Yamagata Univ Yamagata Japan 9908560 Dept Chem, Yamagata 9908560, Japan
Titolo Testata:
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
fascicolo: 9-10, volume: 56, anno: 2001,
pagine: 865 - 871
SICI:
0939-5075(200109/10)56:9-10<865:NAOOAP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-HYDROXYLASE; IRON(III) COMPLEXES; DIOXYGEN MOLECULE; HYDROGEN-PEROXIDE; REDUCING AGENTS; REACTIVITY; MECHANISM; RELEVANCE; DISEASE;
Keywords:
Al(III)-induced neurodegeneration; oxygen activation; tyrosine hydroxylase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Nishida, Y Yamagata Univ, Fac Sci, Dept Chem, Yamagata 9908560, Japan Yamagata Univ Yamagata Japan 9908560 Yamagata 9908560, Japan
Citazione:
Y. Nishida, "Negligible ability of oxygen and peroxide ion activation by Al(III) ion isessential for Al(III)-induced neurodegeneration", Z NATURFO C, 56(9-10), 2001, pp. 865-871

Abstract

The electron densities of the atoms in Fe(II)- or Al(III)-tyrosine hydroxylase (THO) containing oxygen and pterin were calculated by the DFT (Density-functional theory) method. The results obtained are consistent with our previous proposal that oxygen activation in THO proceeds through the formation of an intermediate derived from Fe(H), oxygen, and pterin. Electron donation from substrate to the oxygen molecule is important to cleave the O-O bond, and to give the hydroxylated product. Based on these results, it was concluded that hydroxylation of the aromatic ring does not proceed in the Al(III)-containing THO, and a relationship exists between Al(III) ion and neurodegeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:56:59