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Titolo:
Expansion of phosphatidylcholine and phosphatidylserine/phosphatidylcholine monolayers by differently charged amphiphiles
Autore:
Bialkowska, K; Bobrowska-Hagerstrand, M; Hagerstrand, H;
Indirizzi:
Abo Akad Univ, Dept Biol, FIN-20520 Turku, Finland Abo Akad Univ Turku Finland FIN-20520 ept Biol, FIN-20520 Turku, Finland Univ Wroclaw, Inst Biochem, PL-51148 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-51148 t Biochem, PL-51148 Wroclaw, Poland
Titolo Testata:
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
fascicolo: 9-10, volume: 56, anno: 2001,
pagine: 826 - 830
SICI:
0939-5075(200109/10)56:9-10<826:EOPAP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-CELL SHAPE; HUMAN-ERYTHROCYTES; MEMBRANES; TRANSFORMATIONS; FLUORESCENCE; MECHANISM; LIPOSOMES; DRUGS;
Keywords:
monolayer technique; nonionic detergent; erythrocyte shape;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hagerstrand, H Abo Akad Univ, Dept Biol, FIN-20520 Turku, Finland Abo AkadUniv Turku Finland FIN-20520 0520 Turku, Finland
Citazione:
K. Bialkowska et al., "Expansion of phosphatidylcholine and phosphatidylserine/phosphatidylcholine monolayers by differently charged amphiphiles", Z NATURFO C, 56(9-10), 2001, pp. 826-830

Abstract

The degree and time-course of expansion of palmitoyloleoylphosphatidylcholine (PC) and bovine brain phosphatidylserine (PS)/PC (75:25, mol/mol) monolayers at 32 mN/m caused by differently charged amphiphiles (detergents) added to the sub-phase buffer (pH 7.4, 22 degreesC) were followed. Amphiphileswere added to the sub-phase at a concentration/monolayer area corresponding to the concentration/erythrocytes surface area where sphero-echinocytic or sphero-stomatocytic shapes are induced (0.46-14.6 muM). Nonionic, cationic and anionic amphiphiles expanded the PS/PC monolayer significantly more (1.7-4.2 times) than the PC monolayer. A zwitterionic amphiphile expanded both monolayers to a similar extent. The initial rate of monolayer-expansion was higher for all amphiphiles (1.7-20.4 times) in the PS/PC monolayer thanin the PC monolayer. It is suggested that hydrophobic interactions govern the intercalation of amphiphiles into monolayers, and that monolayer packing, modulated by phospholipid head group interactions and alkyl chain saturation, strongly influence amphiphile intercalation. A possible relation between the monolayer-expanding effect of amphiphiles and their effect on erythrocyte shape is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:55:52