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Titolo:
Tissue specific distribution of Epstein-Barr virus (EBV) BZLF1 gene variants in nasopharyngeal carcinoma (NPC) bearing patients
Autore:
Sacaze, C; Henry, S; Icart, J; Mariame, B;
Indirizzi:
CHU Purpan, CNRS, UPR 2163, Unite Physiopathol Cellulaire & Mol, F-31059 Toulouse 03, France CHU Purpan Toulouse France 03 lulaire & Mol, F-31059 Toulouse 03, France CHU Rangueil, Fac Med, F-31403 Toulouse, France CHU Rangueil Toulouse France F-31403 , Fac Med, F-31403 Toulouse, France
Titolo Testata:
VIRUS RESEARCH
fascicolo: 1-2, volume: 81, anno: 2001,
pagine: 133 - 142
SICI:
0168-1702(200112)81:1-2<133:TSDOEV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HODGKINS-DISEASE; TERMINAL REGION; VIRAL GENOMES; CELLS; DNA; INFECTION; HYBRIDIZATION; POLYMORPHISMS; ASSOCIATION; INDIVIDUALS;
Keywords:
Epstein-Barr virus; nasopharyngeal carcinoma; BZLF1 gene polymorphism; multiple infections; tissue distribution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Mariame, B CHU Purpan, CNRS, UPR 2163, Unite Physiopathol Cellulaire & Mol, Ave Grande Bretagne, F-31059 Toulouse 03, France CHU Purpan Ave Grande Bretagne Toulouse France 03 e 03, France
Citazione:
C. Sacaze et al., "Tissue specific distribution of Epstein-Barr virus (EBV) BZLF1 gene variants in nasopharyngeal carcinoma (NPC) bearing patients", VIRUS RES, 81(1-2), 2001, pp. 133-142

Abstract

Using EBV BNLF1 gene polymorphism, we have recently shown that, in NPC bearing patients, lymphocytes and tumor cells of the same individual were infected by different viruses. It appeared as a rule that EBV infection was by multiple strains in these immunocompetent, HIV negative patients. Our data did not detect any evident association between tumor cells and a particularBNLF1 variant. In the present paper, we extend our analysis to the BZLF1 gene of the viruses present in different sites of the same patients. Only two main variants of the BZLF1 gene were identified. Despite this very weak polymorphism of this locus, our results entirely confirm the very frequent occurrence of multistrain infections in these patients, and the presence of different EBV strains in tumor cells and lymphocytes from the same individual. However, in contrast to our results concerning the BNLF1 gene, the BZLF1 variants appeared to be cell type specific, one being associated mainly with epithelial or tumor cells and the other with lymphocytes. The possible reasons for this distribution are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 20/09/20 alle ore 04:01:32