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Titolo:
Effects of nutrition, social factors and chronic stress on the mouse Leydig cell testosterone production
Autore:
Faldikova, L; Diblikova, I; Canderle, J; Zraly, Z; Veznik, Z; Sulcova, A;
Indirizzi:
Vet Res Inst, CS-62132 Brno, Czech Republic Vet Res Inst Brno Czech Republic CS-62132 CS-62132 Brno, Czech Republic Masaryk Univ, Fac Med, Dept Pharmacol, Brno, Czech Republic Masaryk Univ Brno Czech Republic , Dept Pharmacol, Brno, Czech Republic
Titolo Testata:
VETERINARNI MEDICINA
fascicolo: 6, volume: 46, anno: 2001,
pagine: 160 - 168
SICI:
0375-8427(200106)46:6<160:EONSFA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT MALE-RATS; IMMOBILIZATION STRESS; TESTICULAR STEROIDOGENESIS; REPRODUCTIVE FUNCTIONS; PLASMA; CORTICOSTERONE; FAT; TESTIS; WATER; STATE;
Keywords:
mice; chronic stress; hypothryeosis; potassium nitrate; fat-free diet; individual caging; aggressive and timid behaviour; Leydig cells in vitro; gonadotrophin; testosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Faldikova, L Vet Res Inst, Hudcova 70, CS-62132 Brno, Czech Republic Vet Res Inst Hudcova 70 Brno Czech Republic CS-62132 epublic
Citazione:
L. Faldikova et al., "Effects of nutrition, social factors and chronic stress on the mouse Leydig cell testosterone production", VET MED-CZ, 46(6), 2001, pp. 160-168

Abstract

The testosterone production by Leydig cells of mice adversely affected with nutritional or social factors and exposed to chronic stress was studied in vitro. Both basal and gonadotrophin stimulated testosterone production were highly significantly decreased (P < 0.01) as in groups given the hypothyreotics or potassium nitrate alone as in combination with stress. Stimulated in vitro testosterone production was not significantly changed in groups fed with synthetic diets, however, in mice given modified diets and exposedto stress decreased responsivity of Leydig cells stimulated by gonadotrophin was found. Basal and stimulated testosterone production in vitro in mostof gonadotrophin concentrations was non-significantly lower in mice affected only by stress when compared with undisturbed controls. In isolated malemice the basal testosterone production was significantly (P < 0.05) decreased and gonadotrophin stimulated production highly significantly (P < 0.01)decreased when compared with group caged males, The testosterone production was most severely suppressed in aggressive individuals. Serum testosterone levels were detected in all animals, corticosterone, T-3 and T-4 in selected groups of mice. We can conclude that the testosterone production was adversely affected by nutritional factors, and the impact was more profound when exerted together with chronic stress. The adverse effect of individual caging of male mice was also proved.

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Documento generato il 03/07/20 alle ore 01:20:50