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Titolo:
Reduced renal vascular resistance in response to verapamil during gradatedureter obstruction in pigs
Autore:
Hvistendahl, JJ; Pedersen, TS; Hvistendahl, GM; Djurhuus, JC; Frokiaer, J;
Indirizzi:
Aarhus Univ Hosp, Dept Clin Physiol & Nucl Med, Inst Expt Clin Res, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N pt Clin Res, DK-8200 Aarhus N, Denmark Univ Aarhus, Inst Expt Clin Res, Aarhus, Denmark Univ Aarhus Aarhus Denmark Aarhus, Inst Expt Clin Res, Aarhus, Denmark
Titolo Testata:
UROLOGICAL RESEARCH
fascicolo: 5, volume: 29, anno: 2001,
pagine: 350 - 358
SICI:
0300-5623(200110)29:5<350:RRVRIR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-ANTAGONISTS; HEMODYNAMIC-RESPONSE; CHANNEL BLOCKADE; ANGIOTENSIN-II; BLOCKERS; PRESSURE; DOGS;
Keywords:
verapamil; ureteral obstruction; renal hemodynamics; angiotensin II; pigs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Frokiaer, J Aarhus Univ Hosp, Dept Clin Physiol & Nucl Med, Inst Expt ClinRes, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N DK-8200 Aarhus N, Denmark
Citazione:
J.J. Hvistendahl et al., "Reduced renal vascular resistance in response to verapamil during gradatedureter obstruction in pigs", UROL RES, 29(5), 2001, pp. 350-358

Abstract

Unilateral ureteral obstruction (UUO) is associated with reductions in ipsilateral renal blood flow (RBF) and glomerular filtration rate (GFR) causedby an active preglomerular vasoconstriction, where angiotensin II (ANGII) may be an important mediator. Calcium-channel blockers preferentially dilate preglomerular vessels and abolish the vasoconstrictor actions of ANGII inpreglomerular arterioles of the hydronephrotic rat kidney. In this study, we, therefore, examined the effects of the calcium-channel blocker verapamil (3.65 mug/kg per minute i.v.) on RBF, GFR and renal vascular resistance (RVR) in our pig model with UUO, where ultrasonic flow probes are mounted oneach renal artery and catheters placed in the abdominal aorta and both renal veins. Verapamil treatment was associated with a 34% reduction in ipsilateral RBF (from 182.6 +/- 20.5 ml/min to 120.6 +/- 12.2 ml/min, P < 0.001),which was similar to the 27% reduction in ipsilateral RBF in controls (from 194.6 <plus/minus> 13.1 ml/min to 140.6 +/- 15.2 ml/min, P < 0.001). Ipsilateral GFR was reduced by 70% in the verapamil-treated pigs (from 29.0 <plus/minus> 2.6 to 8.5 +/- 0.9 ml/min, P < 0.001) and by 73% in control animals (from 29.2 <plus/minus> 3.1 to 7.6 +/- 12.1 ml/min, p < 0.001). However,the increase in RVR was significantly attenuated in the verapamil-treated pigs. Ipsilateral RVR increased by 19% in the verapamil-treated pigs (from 0.585 <plus/minus> 0.076 to 0.726 +/- 0.081 mmHg/min/ml, P < 0.05) comparedwith a 34% increase in control pigs (from 0.560 <plus/minus> 0.056 to 0.854 +/- 0.091 mmHg/min per milliliter, P < 0.001), suggesting that an intact calcium-channel may be important for the increase in renal vascular resistance during unilateral ureter obstruction. In conclusion, the present study shows that verapamil is able to modulate the increase in renal vascular resistance in response to increased pelvic pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:06:28