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Titolo:
Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma
Autore:
van Rensen, ELJ; Stirling, RG; Scheerens, J; Staples, K; Sterk, PJ; Barnes, PJ; Chung, KF;
Indirizzi:
Natl Heart & Lung Inst, Imperial Coll Sch Med, Dept Thorac Med, London SW36LY, England Natl Heart & Lung Inst London England SW3 6LY ed, London SW36LY, England Leiden Univ, Med Ctr, Dept Pulm, Leiden, Netherlands Leiden Univ Leiden Netherlands Med Ctr, Dept Pulm, Leiden, Netherlands
Titolo Testata:
THORAX
fascicolo: 12, volume: 56, anno: 2001,
pagine: 935 - 940
SICI:
0040-6376(200112)56:12<935:EFSRTP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY HYPERRESPONSIVENESS; TRANSGENIC MICE; BRONCHIAL HYPERREACTIVITY; EOSINOPHIL TRAFFICKING; INHALED INTERLEUKIN-5; SPUTUM INDUCTION; IL-5 RECEPTOR; ATOPIC ASTHMA; BONE-MARROW; IN-VIVO;
Keywords:
asthma; eosinophil; interleukin 5; bronchial responsiveness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, KF Natl Heart & Lung Inst, Imperial Coll Sch Med, Dept Thorac Med, London SW36LY, England Natl Heart & Lung Inst London England SW3 6LY SW36LY, England
Citazione:
E.L.J. van Rensen et al., "Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma", THORAX, 56(12), 2001, pp. 935-940

Abstract

Background-Interleukin 5 (IL-5) has an important role in mobilisation of eosinophils from the bone marrow and in their subsequent terminal differentiation. A study was undertaken to determine whether inhaled and intravenous IL-5 could induce pulmonary eosinophilia and bronchial hyperresponsiveness (BHR) independently of these effects. Methods-Nine mild asthmatics received inhaled (15 mug) or intravenous (2 mug) IL-5 or placebo in random order in a double blind, crossover study. Blood samples were taken before and at 0.5, 1, 2, 3, 4, 5, 24, and 72 hours following IL-5 or placebo, and bronchial responsiveness (PC20 methacholine) and eosinophil counts in induced sputum were determined. Results-Serum IL-5 levels were markedly increased 30 minutes after intravenous IL-5 (p=0.002), and sputum IL-5 levels increased 4 and 24 hours after inhaled IL-5 (p <0.05). Serum eotaxin was raised 24 hours after intravenousIL-5 but not after inhaled IL-5 or placebo. Blood eosinophils were markedly reduced 0.5-2 hours after intravenous IL-5 (p <0.05), followed by an increase at 3, 4, 5, and 72 hours (p <0.05). Sputum eosinophils rose significantly in all three groups at 24 hours but there were no differences between the groups. Bronchial responsiveness was not affected by IL-5. Conclusion-The effects of IL-5 appear to be mainly in the circulation, inducing peripheral mobilisation of eosinophils to the circulation without anyeffect on eosinophil mobilisation in the lungs or on bronchial responsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:26:59