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Titolo:
Stability of exploratory eye movements as a marker of schizophrenia - a WHO multi-center study
Autore:
Kojima, T; Matsushima, E; Ohta, K; Toru, M; Han, YH; Shen, YC; Moussaoui, D; David, I; Sato, K; Yamashita, I; Kathmann, N; Hippius, H; Thavundayil, JX; Lal, S; Nair, NPV; Potkin, SG; Prilipko, L;
Indirizzi:
Nihon Univ, Sch Med, Dept Neuropsychiat, Itabashi Ku, Tokyo 1738610, JapanNihon Univ Tokyo Japan 1738610 ychiat, Itabashi Ku, Tokyo 1738610, Japan Tokyo Med & Dent Univ, Grad Sch, Sect Liaison Psychiat & Palliat Med, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Grad Sch, Dept Psychiat & Behav Sci, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Beijing Med Univ, Inst Mental Hlth, Beijing 100083, Peoples R China Beijing Med Univ Beijing Peoples R China 100083 100083, Peoples R China Univ Casablanca, Ctr Psychiat, Casablanca, Morocco Univ Casablanca Casablanca Morocco a, Ctr Psychiat, Casablanca, Morocco Psychiat Ctr Praha, Prague 18103 8, Czech Republic Psychiat Ctr Praha Prague Czech Republic 18103 8 18103 8, Czech Republic Hokkaido Univ, Sch Med, Dept Psychiat & Neurol, Sapporo, Hokkaido 0608648,Japan Hokkaido Univ Sapporo Hokkaido Japan 0608648 poro, Hokkaido 0608648,Japan Univ Munich, Psychiat Klin & Poliklin, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 n & Poliklin, D-80336 Munich, Germany Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada Douglas Hosp Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada Univ Calif Irvine, Brain Imaging Ctr, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 n Imaging Ctr, Irvine, CA 92697 USA WHO, Div Mental Hlth & Prevent Subst Abuse, CH-1211 Geneva 27, SwitzerlandWHO Geneva Switzerland 27 nt Subst Abuse, CH-1211 Geneva 27, Switzerland
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 52, anno: 2001,
pagine: 203 - 213
SICI:
0920-9964(200112)52:3<203:SOEEMA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACKING DYSFUNCTIONS; PERCEPTION;
Keywords:
exploratory eye movements; responsive search score; vulnerability marker; discriminant analysis; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kojima, T Nihon Univ, Sch Med, Dept Neuropsychiat, Itabashi Ku, Oyaguchi Kamimachi 30-1, Tokyo 1738610, Japan Nihon Univ Oyaguchi Kamimachi 30-1 Tokyo Japan 1738610 0, Japan
Citazione:
T. Kojima et al., "Stability of exploratory eye movements as a marker of schizophrenia - a WHO multi-center study", SCHIZOPHR R, 52(3), 2001, pp. 203-213

Abstract

The exploratory eye movements of patients with schizophrenia reportedly differ from those of patients without schizophrenia and healthy controls. In an attempt to determine whether exploratory eye movements provide valid markers for schizophrenia, the present collaborative study was conducted in six countries to analyze the stability of and variation in the following parameters of exploratory eye movements: the number of eye fixations (NEFs) andmean eye scanning length (MESL) in a retention task; the cognitive search score (CSS) that indicates how frequently the eye focused on each importantarea of a figure in order to recognize it in a comparison task, and the responsive search score (RSS), which reflects the frequency of eye fixations on each section of a figure in response to questioning in a comparison task. In addition, we investigated the validity of the currently employed discriminant function to extract a common feature of schizophrenia by applying it to the findings of the present study. The exploratory eye movements of 145 patients with schizophrenia, 116 depressed patients and 124 healthy controls at seven WHO collaborative centers in six countries were measured usingeye mark recorders during viewing of stationary S-shaped figures in two sequential tasks. The RSSs of patients with schizophrenia were found to be significantly lower than those of depressed patients or healthy controls irrespective of geographical location, with no significant difference existing between the RSSs for depressed patients and those for healthy controls. By inserting the RSS and NEF data for each subject into the formula used to calculate discriminant function, patients with schizophrenia could be discriminated from depressed patients and healthy controls with a sensitivity of 89.0% and a specificity of 86.7%. The RSS is an exploratory eye movement parameter that detected schizophrenia irrespective of culture, race and various other subject variables. Furthermore, it is indicative of the stable, significant difference that exists between subjects with and without schizophrenia. The results of discriminant analysis confirm the previously reported validity of discriminant function. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/05/20 alle ore 13:34:05