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Titolo:
Differentiating between low and high susceptibility to schizophrenia in twins: the significance of dermatoglyphic indices in relation to other determinants of brain development
Autore:
van Oel, CJ; Baare, WFC; Pol, HEH; Haag, J; Balazs, J; Dingemans, A; Kahn, RS; Sitskoorn, MM;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Psychiat, NL-3584 CX Utrecht, Netherlands UnivUtrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 3, volume: 52, anno: 2001,
pagine: 181 - 193
SICI:
0920-9964(200112)52:3<181:DBLAHS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
B RIDGE COUNT; VENTRICULAR ENLARGEMENT; DIAGNOSTIC INTERVIEW; PLACENTAL PROXIMITY; MONOZYGOTIC TWINS; CORPUS-CALLOSUM; EARLY-ONSET; ASYMMETRY; SIZE; COMPLICATIONS;
Keywords:
schizophrenia; dermatoglyphics; susceptibility; brain development; placental dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: van Oel, CJ Leiden Univ, Med Ctr, Dept Gynaecol K6 76, Albinusdreef 2,POB 9600, NL-2300 RC Leiden, Netherlands Leiden Univ Albinusdreef 2,POB 9600 Leiden Netherlands NL-2300 RC
Citazione:
C.J. van Oel et al., "Differentiating between low and high susceptibility to schizophrenia in twins: the significance of dermatoglyphic indices in relation to other determinants of brain development", SCHIZOPHR R, 52(3), 2001, pp. 181-193

Abstract

Both the skin and the brain develop from the same ectoderm and it is thought, therefore, that dermatoglyphics are informative for early disturbances in brain development in schizophrenia. This study was aimed at investigating the differences in both digital and palmar dermatoglyphic indices betweentwins discordant for schizophrenia and control twins. Furthermore, the significance of dermatoglyphic indices in relation to other determinants of brain development with regard to the susceptibility to schizophrenia was investigated. Data on dermatoglyphic indices of the hand and the palm were obtained from 21 same-sex discordant and 37 same-sex control twins. For 19 discordant and 25 control twins, there was also data available on brain volumes. Non-genetic intra-uterine circumstances early in pregnancy (10-13 weeks of gestation) are associated with a susceptibility to schizophrenia, since both the twins with schizophrenia and the unaffected co-twins showed more fluctuating asymmetry of the finger ridges (P < 0.01), and marginally higher absolute finger ridge counts (P = 0.06) than control twin pairs. Fluctuating asymmetry of the finger ridges was as important as whole brain and left hippocampal volumes in differentiating twins with a high susceptibility to schizophrenia from those with a low susceptibility. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 04/04/20 alle ore 12:07:00