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Titolo:
Atypical anti-psychotics: review article.
Autore:
Garcia-Anaya, M; Apiquian, R; Fresan, A;
Indirizzi:
Inst Nacl Psiquiatria Ramon Fuente, Subdirecc Invest Clin, San Lorenzo Huipulco, Mexico City 14370, DF, Mexico Inst Nacl Psiquiatria Ramon Fuente Mexico City DF Mexico 14370 DF, Mexico
Titolo Testata:
SALUD MENTAL
fascicolo: 5, volume: 24, anno: 2001,
pagine: 37 - 43
SICI:
0185-3325(200110)24:5<37:AARA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
SPA
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; NEUROLEPTIC MALIGNANT SYNDROME; DOUBLE-BLIND PET; WEIGHT-GAIN; SCHIZOPHRENIC-PATIENTS; ANTIPSYCHOTIC-DRUGS; DIABETES-MELLITUS; CLOZAPINE; AMISULPRIDE; RISPERIDONE;
Keywords:
schizophrenia; atypical antipsychotics; adverse effects; dissociation constant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Apiquian, R Inst Nacl Psiquiatria Ramon Fuente, Subdirecc Invest Clin, SanLorenzo Huipulco, Xochimilco 101, Mexico City 14370, DF, Mexico Inst Nacl Psiquiatria Ramon Fuente Xochimilco 101 Mexico City DF Mexico 14370
Citazione:
M. Garcia-Anaya et al., "Atypical anti-psychotics: review article.", SALUD MENT, 24(5), 2001, pp. 37-43

Abstract

This review elucidates a new concept for the classification of atypical antipsychotics based on their mechanism of action. The primary aim in the development of an antipsychotic is that of increasing its efficacy and decreasing the frequency of adverse effects. Atypical antipsychotics have reached this goal by different pharmacological action mechanisms. Recently, a new model x as suggested for explaining the action mechanism of atypical antipsychotics. This model suggests that atypical antipsychoticshave a constant of faster dissociation from the dopaminergic receptor D2, which modulates antipsychotic response, conditioning a lower frequency of extrapyramidal symptoms and a lower prolactin elevation, which are the essential features of an atypical antipsychotic. To define an antipsychotic as atypical it should prove its efficacy in thepositive and the negative symptoms of schizophrenia; it should be outstandingly efficient in patients with partial response or lack of it to typical antipsychotics, and it must have at least two of the following properties: no association with subjective dysphoria, low sedative effect, few cardiac/autonomic side effects, mild elevation of prolactin levels, lower associated sexual dysfunction and minimal weight gain. It has been recently proposedthat atypical antipsychotics must show their efficacy in the treatment of depressive symptoms and cognitive deficits associated to schizophrenia. According to these criteria the following drugs are considered as atypicalantipsychotics: risperidone, olanzapine, quetiapine, ziprasidone, amisulpride, zotepine, iloperidone, aripiprazole and clozapine. These properties offer advantages over conventional antipsychotics, nevertheless, atypical antipsychotics have been associated with some adverse effects such as neuroleptic malignant syndrome, cardiovascular effects, weight gain, prolactin elevation, diabetes mellitus and hyperlipidemia, which are summarized in this review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:18:53