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Titolo:
Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO(+) to RA(+) phenotype
Autore:
Wedderburn, LR; Jeffery, R; White, H; Patel, A; Varsani, H; Linch, D; Murray, K; Woo, P;
Indirizzi:
Inst Child Hlth, Rheumatol Unit, London WC1N 1EH, England Inst Child HlthLondon England WC1N 1EH l Unit, London WC1N 1EH, England Univ Coll London, Dept Mol Pathol, London WC1E 6BT, England Univ Coll London London England WC1E 6BT athol, London WC1E 6BT, England Inst Child Hlth, Mol Immunol Unit, London WC1N 1EH, England Inst Child Hlth London England WC1N 1EH l Unit, London WC1N 1EH, England Univ Coll London Hosp, Dept Haematol, London, England Univ Coll London Hosp London England sp, Dept Haematol, London, England
Titolo Testata:
RHEUMATOLOGY
fascicolo: 11, volume: 40, anno: 2001,
pagine: 1299 - 1307
SICI:
1462-0324(200111)40:11<1299:ASCTFP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUVENILE CHRONIC ARTHRITIS; HUMANIZED MONOCLONAL-ANTIBODY; SEVERE APLASTIC-ANEMIA; HIGH-DOSE CHEMOTHERAPY; RHEUMATOID-ARTHRITIS; PERIPHERAL-BLOOD; CLONAL EXPANSIONS; HEMATOPOIETIC PROGENITORS; MARROW-TRANSPLANTATION; IMMUNE RECONSTITUTION;
Keywords:
T-cell receptor; repertoire; CD45; memory; autologous stem cell transplantation; vasculitis; immune reconstitution; high-dose immunosuppression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Wedderburn, LR Inst Child Hlth, Rheumatol Unit, 30 Guilford St, London WC1N 1EH, England Inst Child Hlth 30 Guilford St London England WC1N 1EH and
Citazione:
L.R. Wedderburn et al., "Autologous stem cell transplantation for paediatric-onset polyarteritis nodosa: changes in autoimmune phenotype in the context of reduced diversity of the T- and B-cell repertoires, and evidence for reversion from the CD45RO(+) to RA(+) phenotype", RHEUMATOLOG, 40(11), 2001, pp. 1299-1307

Abstract

We have studied immune reconstitution in a patient with paediatric-onset polyarteritis nodosa treated with high-dose immuno suppressive agents followed by stem cell rescue. The patient developed several new autoimmune phenomena over the 18 months after immunosuppression and stem cell rescue. Flow cytometry, reverse transcription-polymerase chain reaction (RT-PCR) heteroduplex and isotype-specific RT-PCR analysis of immunoglobulin expression showed that the T- and B-cell repertoires were highly restricted in the first few months after treatment. The dominant T-cell clones seen after reconstitution were persistently expanded, were different from those which could be demonstrated before autologous stem cell transplantation, and were in the CD8(+) population. Our data also show that 12 months after treatment these expanded T-cell clones were within the CD45RA(+) population, suggesting that reversion from the CD45RO(+) to the CD45RA phenotype had occurred in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:35:26