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Titolo:
Persistent maternally derived peripheral microchimerism is associated withthe juvenile idiopathic inflammatory myopathies
Autore:
Artlett, CM; Miller, FW; Rider, LG;
Indirizzi:
Thomas Jefferson Univ, Div Rheumatol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA US FDA, Ctr Biol Evaluat & Res, Div Monoclonal Antibodies, Bethesda, MD USA US FDA Bethesda MD USA Res, Div Monoclonal Antibodies, Bethesda, MD USA NIAMSD, Arthrit & Rheumatism Branch, NIH, Bethesda, MD 20892 USA NIAMSD Bethesda MD USA 20892 eumatism Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
RHEUMATOLOGY
fascicolo: 11, volume: 40, anno: 2001,
pagine: 1279 - 1284
SICI:
1462-0324(200111)40:11<1279:PMDPMI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC-SCLEROSIS; CELLS; DERMATOMYOSITIS; ORIGIN; IDENTIFICATION; POLYMYOSITIS; ANTIGENS; DISEASE; LIFE;
Keywords:
microchimerism; maternal-fetal exchange; dermatomyositis; polymyositis; graft versus host reaction; inflammatory myopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Artlett, CM Thomas Jefferson Univ, Div Rheumatol, 233 S 10th St, Philadelphia, PA 19107 USA Thomas Jefferson Univ 233 S 10th St Philadelphia PA USA 19107
Citazione:
C.M. Artlett et al., "Persistent maternally derived peripheral microchimerism is associated withthe juvenile idiopathic inflammatory myopathies", RHEUMATOLOG, 40(11), 2001, pp. 1279-1284

Abstract

Objective. Fetal cells have been demonstrated in the active lesions of adult women with systemic sclerosis. Because the juvenile idiopathic inflammatory myopathies (JIIM) share clinical and histopathological features with systemic sclerosis and graft-vs-host disease, we explored the possibility that maternal cells persist and play a role in the pathogenesis of JIIM. Methods. DNA samples extracted from peripheral blood of 28 JIIM patients (14 females. 14 males) and 23 healthy controls were assessed for microchimerism by the HLA Cw polymerase chain reaction method. HLA Cw alleles from eight mothers and three healthy siblings of JIIM patients were also examined. Results. A microchimeric allele was identified in 19 of 26 JIIM patients whose data were able to be interpreted, compared with two of 21 healthy controls (P<0.001). Subjects with microchimerism ranged in age from 4 to 28 yr. In eight cases in which maternal peripheral blood was available. the additional Cw allele present in the patients was confirmed to be identical to a maternal allele. Three healthy siblings of JIIM patients did not have evidence of a microchimeric Cw allele. Conclusion. Maternal cells can persist in the peripheral blood of their children up to three decades after birth, and are found in a higher proportion in JIIM patients compared with controls. These findings, with other data,suggest that maternal cells may be involved in the immunopathogenesis of JIIM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:46:43