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Titolo:
Mechanisms of angiogenesis: clinical and therapeutic applications.
Autore:
Couffinhal, T; Dufourcq, P; Daret, D; Duplaa, C;
Indirizzi:
Hop Cardiol, Serv Cardiol & Malad Vasc, F-33604 Pessac, France Hop Cardiol Pessac France F-33604 l & Malad Vasc, F-33604 Pessac, France Inserm U441, F-33600 Pessac, France Inserm U441 Pessac France F-33600Inserm U441, F-33600 Pessac, France
Titolo Testata:
REVUE DE MEDECINE INTERNE
fascicolo: 11, volume: 22, anno: 2001,
pagine: 1064 - 1082
SICI:
0248-8663(200111)22:11<1064:MOACAT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
FRE
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; COLLATERAL VESSEL DEVELOPMENT; CORONARY-ARTERY DISEASE; TUMOR ANGIOGENESIS; TIE2 RECEPTOR; HEART-DISEASE; GENE-TRANSFER; MATRIX METALLOPROTEINASES; INTEGRIN ALPHA(V)BETA(3); MYOCARDIAL ANGIOGENESIS;
Keywords:
angiogenesis; endothelial cell; smooth muscle cell; tumor; myocardial ischemia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Couffinhal, T Hop Cardiol, Serv Cardiol & Malad Vasc, Ave Magellan, F-33604 Pessac, France Hop Cardiol Ave Magellan Pessac France F-33604 ssac, France
Citazione:
T. Couffinhal et al., "Mechanisms of angiogenesis: clinical and therapeutic applications.", REV MED IN, 22(11), 2001, pp. 1064-1082

Abstract

Purpose. - Endothelial and smooth muscle cells interact with each other toform new blood vessels. In this review, the cellular and molecular mechanism underlying the formation of the primary vascular plexus (vasculogenesis), the sprouting of further blood vessels (angiogenesis) and their maturation via recruitment of smooth muscle cells (arteriogenesis) during physiological and pathological conditions are summarized. Current knowledge and key point. - The concept of angiogenesis is studied in tumoral and cardiovascular pathology. Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a promising approach in cardiovascular diseases. Conversely, inhibition of the action of key regulators of angiogenesis is a new pathway for the treatment of solid tumors and metastasis. Future prospects and projects. - These concepts are being tested now in clinical trials in the oncology or cardiovascular fields. Some trials are reported in this review with their potential adverse effects, limits and developments in the future. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:31:54