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Titolo:
Widespread anatomical abnormalities of grey and white matter structure in tuberous sclerosis
Autore:
Ridler, K; Bullmore, ET; De Vries, PJ; Suckling, J; Barker, GJ; Meara, SJP; Williams, SCR; Bolton, PF;
Indirizzi:
Univ Cambridge, Brain Mapping Unit, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ nit, Cambridge CB2 2QQ, England Univ Cambridge, Dev Psychiat Sect, Dept Psychiat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ iat, Cambridge CB2 2QQ, England Univ London, Inst Neurol, Dept Clin Neurol, London, England Univ London London England st Neurol, Dept Clin Neurol, London, England Univ London Kings Coll, Inst Psychiat, Dept Neurol, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Univ London Kings Coll, Dept Biostat & Comp, Brain Image Anal Unit, LondonWC2R 2LS, England Univ London Kings Coll London England WC2R 2LS , LondonWC2R 2LS, England Univ London Kings Coll, Dept Hlth Care Elderly, Clin Age Res Unit, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England
Titolo Testata:
PSYCHOLOGICAL MEDICINE
fascicolo: 8, volume: 31, anno: 2001,
pagine: 1437 - 1446
SICI:
0033-2917(200111)31:8<1437:WAAOGA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-TISSUE CLASSIFICATION; MAGNETIC-RESONANCE IMAGES; MR-IMAGES; IDENTIFICATION; COMPLEX; VOXEL; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ridler, K Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Brain Mapping Unit, Box 189, Cambridge CB2 2QQ, England Univ Cambridge Box 189 CambridgeEngland CB2 2QQ 2 2QQ, England
Citazione:
K. Ridler et al., "Widespread anatomical abnormalities of grey and white matter structure in tuberous sclerosis", PSYCHOL MED, 31(8), 2001, pp. 1437-1446

Abstract

Background. Neuroimaging studies of tuberous sclerosis complex (TSC) have previously focused mainly on tubers or subependymal nodules. Subtle pathological changes in the structure of the brain have not been studied in detail. Computationally intensive techniques for reliable morphometry of brain structure are useful in disorders like TSC, where there is little prior data to guide selection of regions of interest. Methods. Dual-echo, fast spin-echo MRI data were acquired from 10 TSC patients of normal intelligence and eight age-matched controls. Between-group differences in grey matter, white matter and cerebrospinal fluid were estimated at each intracerebral voxel after registration of these images in standard space; a permutation test based on spatial statistics was used for inference. CSF-attenuated FLAIR images were acquired for neuroradiological rating of tuber number. Results. Significant deficits were found in patients, relative to comparison subjects, of grey matter volume bilaterally in the medial temporal lobes, posterior cingulate gyrus, thalamus and basal ganglia, and unilaterally in right fronto-parietal cortex (patients - 20 %). We also found significantand approximately symmetrical deficits of central white matter involving the longitudinal fasciculi and other major intrahemispheric tracts (patients- 21 %); and a bilateral cerebellar region of relative white matter excess(patients + 28 %). Within the patient group, grey matter volume in limbic and subcortical regions of deficit was negatively correlated with tuber count. Conclusions. Neuropathological changes associated with TSC may be more extensive than hitherto suspected, involving radiologically normal parenchymalstructures as well as tubers, although these two aspects of the disorder may be correlated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:05:47