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Titolo:
Distributed grey and white matter deficits in hyperkinetic disorder: MRI evidence for anatomical abnormality in an attentional network
Autore:
Overmeyer, S; Bullmore, ET; Suckling, J; Simmons, A; Williams, SCR; Santosh, PJ; Taylor, E;
Indirizzi:
Univ Cambridge, Dept Psychiat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ iat, Cambridge CB2 2QQ, England Guys Kings & St Thomas Sch Med, London, England Guys Kings & St Thomas SchMed London England Sch Med, London, England Inst Psychiat, London, England Inst Psychiat London EnglandInst Psychiat, London, England
Titolo Testata:
PSYCHOLOGICAL MEDICINE
fascicolo: 8, volume: 31, anno: 2001,
pagine: 1425 - 1435
SICI:
0033-2917(200111)31:8<1425:DGAWMD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERACTIVITY DISORDER; CAUDATE-NUCLEUS; CORPUS-CALLOSUM; MORPHOMETRIC ANALYSIS; BRAIN; MORPHOLOGY; DYSFUNCTION; CHILDREN; IMAGES; VOXEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Bullmore, ET Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ e CB2 2QQ, England
Citazione:
S. Overmeyer et al., "Distributed grey and white matter deficits in hyperkinetic disorder: MRI evidence for anatomical abnormality in an attentional network", PSYCHOL MED, 31(8), 2001, pp. 1425-1435

Abstract

Background. Previous neuroimaging studies of children with attention deficit hyperactivity disorder (ADHD) have demonstrated anatomic and functional abnormalities predominantly in frontal and striatal grey matter. Here we report the use of novel image analysis methods, which do not require prior selection of regions of interest, to characterize distributed morphological deficits of both grey and white matter associated with ADHD. Methods. Eighteen children with a refined phenotype of ADHD, who also met ICD-10 criteria for hyperkinetic disorder (mean age 10(.)4 years), and 16 normal children (mean age 10(.)3 years) were compared using magnetic resonance imaging. The groups were matched for handedness, sex, height, weight andhead circumference. Morphological differences between groups were estimated by fitting a linear model at each voxel in standard space, applying a threshold to the resulting voxel statistic maps to generate clusters of spatially contiguous suprathreshold voxels, and testing cluster 'mass', or the sum of suprathreshold voxel statistics in each 2D cluster, by repeated randomresampling of the data. Results. The hyperkinetic children had significant grey matter deficits inright superior frontal gyrus (Brodmann area (BA) 8/9), right posterior cingulate gyrus (BA 30) and the basal ganglia bilaterally (especially right globus pallidus and putamen). They also demonstrated significant central white matter deficits in the left hemisphere anterior to the pyramidal tracts and superior to the basal ganglia. Conclusions. This pattern of spatially distributed grey matter deficit in the right hemisphere is compatible with the hypothesis that ADHD is associated with disruption of a large scale neurocognitive network for attention. The left hemispheric white matter deficits may be due to dysmyelination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:03:04