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Titolo:
Regulation of cyclic peptide biosynthesis in a plant pathogenic fungus by a novel transcription factor
Autore:
Pedley, KF; Walton, JD;
Indirizzi:
Michigan State Univ, Dept Energy, Plant Res Lab, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 s Lab, E Lansing, MI 48824 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 24, volume: 98, anno: 2001,
pagine: 14174 - 14179
SICI:
0027-8424(20011120)98:24<14174:ROCPBI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORIZONTAL GENE-TRANSFER; HOST-SELECTIVE TOXIN; COCHLIOBOLUS-CARBONUM; HC-TOXIN; ASPERGILLUS-NIDULANS; HISTONE DEACETYLASE; ANKYRIN REPEAT; MAIZE; DNA; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Walton, JD Michigan State Univ, Dept Energy, Plant Res Lab, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 nsing, MI 48824 USA
Citazione:
K.F. Pedley e J.D. Walton, "Regulation of cyclic peptide biosynthesis in a plant pathogenic fungus by a novel transcription factor", P NAS US, 98(24), 2001, pp. 14174-14179

Abstract

Strains of the filamentous fungus Cochliobolus carbonum that produce the host-selective compound HC-toxin, a cyclic tetrapeptide, are highly virulenton certain genotypes of maize (Zea mays L.). Production of HC-toxin is under the control of a complex locus, TOX2, which is composed of at least seven linked and duplicated genes that are present only in toxin-producing strains of C. carbonum. one of these genes, TOXE, was earlier shown to be required for the expression of the other TOX2 genes. TOXE has four ankyrin repeats and a basic region similar to those found in basic leucine zipper (bZIP)proteins, but lacks any apparent leucine zipper. Here we show that TOXE isa DNA-binding protein that recognizes a ten-base motif (the "tox-box") without dyad symmetry that is present in the promoters of all of the known TOX2 genes. Both the basic region and the ankyrin repeats are involved in DNA binding. A region of TOXE that includes the first ankyrin repeat is necessary and sufficient for transcriptional activation in yeast. The data indicate that TOXE is the prototype of a new family of transcription factor, so far found only in plant-pathogenic fungi. TOXE plays a specific regulatory role in HC-toxin production and, therefore, pathogenicity by C. carbonum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:15:01