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Titolo:
The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms?
Autore:
Akwa, Y; Ladurelle, N; Covey, DF; Baulieu, EE;
Indirizzi:
INSERM, U488, F-94276 Le Kremlin Bicetre, France INSERM Le Kremlin Bicetre France F-94276 4276 Le Kremlin Bicetre, France Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Pharmacol, St Louis, MO 63110 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 24, volume: 98, anno: 2001,
pagine: 14033 - 14037
SICI:
0027-8424(20011120)98:24<14033:TSEOPS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID(A) RECEPTOR MODULATION; SYNAPTIC PLASTICITY; ACETYLCHOLINE-RELEASE; STEROID MODULATION; NMDA ANTAGONIST; SPATIAL MEMORY; AGED RATS; INFUSION; DEFICITS; TASK;
Keywords:
spatial memory; Y-maze; N-methyl-D-aspartate receptor; 2-amino-5-phosphovaleric acid; rodents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Akwa, Y INSERM, U488, 80 Rue Gen Leclerc, F-94276 Le Kremlin Bicetre, France INSERM 80 Rue Gen Leclerc Le Kremlin Bicetre France F-94276 rance
Citazione:
Y. Akwa et al., "The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms?", P NAS US, 98(24), 2001, pp. 14033-14037

Abstract

The demonstration that the neurosteroid pregnenolone sulfate (PREGS) is active on memory function at both the physiological and pharmacological levels led to us examining in detail the effects of the steroid on spatial working memory by using a two-trial recognition task in a Y-maze, a paradigm based on the natural drive in rodents to explore a novel environment. Dose-response studies in young male adult Sprague-Dawley rats and Swiss mice, afterthe postacquisition intracerebroventricular injection of steroid, showed an U-inverted curve for memory performance and indicated a greater responsiveness in rats compared with mice. Remarkably, the synthetic (-) enantiomer of PREGS not only also displayed promnesiant activity, but its potency was 10 times higher than that of the natural steroid. Intracerebroventricular coadministration experiments with DL-2-amino-5-phosphonovaleric acid, a competitive selective antagonist of the N-methyl-D-aspartate receptor, abolished the memory-enhancing effect of PREGS, but not that of the PREGS enantiomer, evoking enantiomeric selectivity at the N-methyl-D-aspartate receptor and/or different mechanisms for the promnestic function of the two enantiomers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:24:27