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Titolo:
Neurochemical and behavioural effects of chronic aldicarb administration in rats
Autore:
Palumbo, G; Bacchi, S; Coppolino, MF; Pantaleoni, GC;
Indirizzi:
Univ Aquila, Inst Med Pharmacol, Dept Internal Med, I-67100 Laquila, ItalyUniv Aquila Laquila Italy I-67100 t Internal Med, I-67100 Laquila, Italy
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 5, volume: 89, anno: 2001,
pagine: 249 - 254
SICI:
0901-9928(200111)89:5<249:NABEOC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCOMOTOR-ACTIVITY; MEMORY FACILITATION; CHOLINERGIC SYSTEM; MAZE PERFORMANCE; DOPAMINE; NEUROTOXICITY; SCOPOLAMINE; CARBARYL; CORTEX; ACETYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Palumbo, G Univ Aquila, Inst Med Pharmacol, Dept Internal Med, Via S Sisto,22-E, I-67100 Laquila, Italy Univ Aquila Via S Sisto,22-E Laquila Italy I-67100 uila, Italy
Citazione:
G. Palumbo et al., "Neurochemical and behavioural effects of chronic aldicarb administration in rats", PHARM TOX, 89(5), 2001, pp. 249-254

Abstract

Changes in neurochemical parameters, behavioural and memory performances due to aldicarb (a carbamate pesticide) treatment was investigated after chronic oral administration in rats. Rats received water, or aldicarb 1 ppb (=0.12 g/kg/day), aldicarb 10 ppb (= 1.2 g/kg/day) and aldicarb 100 ppb (= 12 g/kg/day) for 4 months. The locomotor and explorative activities were reduced, and aldicarb significantly decreased brain AChE activity while an increase was found in the passive avoidance and water-maze performance. In thestriatum, aldicarb 10 ppb and 100 ppb, significantly reduced DOPA but not DOPAC concentrations, while the 10 ppb and 100 ppb doses significant increased DA levels. Aldicarb did not affect DA, DOPA and DOPAC levels in the accumbens. The neuropharmacologic effects of chronic dosing with aldicarb, AChE inhibition and dopaminergic modulation could be useful for treatment of memory deficits related to CNS disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:12:52