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Titolo:
The role of neuronal and extraneuronal plasma membrane transporters in theinactivation of peripheral catecholamines
Autore:
Eisenhofer, G;
Indirizzi:
NINCDS, Clin Neurocardiol Sect, NIH, Bethesda, MD 20892 USA NINCDS Bethesda MD USA 20892 urocardiol Sect, NIH, Bethesda, MD 20892 USA
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 1, volume: 91, anno: 2001,
pagine: 35 - 62
SICI:
0163-7258(200107)91:1<35:TRONAE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC CATION TRANSPORTER; HUMAN NOREPINEPHRINE TRANSPORTER; HUMAN DOPAMINE TRANSPORTER; CARDIAC SYMPATHETIC-NERVES; ANGIOTENSIN-II REGULATION; CONGESTIVE-HEART-FAILURE; PROTEIN-KINASE-C; RAT TAIL ARTERY; NONNEURONAL MONOAMINE TRANSPORTERS; IDIOPATHIC DILATED CARDIOMYOPATHY;
Keywords:
norepinephrine; dopamine; epinephrine; sympathetic nervous system; transporter; uptake;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
303
Recensione:
Indirizzi per estratti:
Indirizzo: Eisenhofer, G NINCDS, Clin Neurocardiol Sect, NIH, Bldg 10,Room 6N 252,10 Ctr Dr,MSC 1620, Bethesda, MD 20892 USA NINCDS Bldg 10,Room 6N 252,10 Ctr Dr,MSC 1620 Bethesda MD USA 20892
Citazione:
G. Eisenhofer, "The role of neuronal and extraneuronal plasma membrane transporters in theinactivation of peripheral catecholamines", PHARM THERA, 91(1), 2001, pp. 35-62

Abstract

Catecholamines are translocated across plasma membranes by transporters that belong to two large families with mainly neuronal or extraneuronal locations. In mammals, neuronal uptake of catecholamines involves the dopamine transporter (DAT) at dopaminergic neurons and the norepinephrine transporter(NET) at noradrenergic neurons. Extraneuronal uptake of catecholamines is mediated by organic cation transporters (OCTs), including the classic corticosterone-sensitive extraneuronal monoamine transporter. Catecholamine transporters function as part of uptake and metabolizing systems primarily responsible for inactivation of transmitter released by neurons. Additionally, the neuronal catecholamine transporters, recycle catecholamines for rerelease, thereby reducing requirements for transmitter synthesis. In a broader sense, catecholamine transporters function as part of integrated systems where catecholamine synthesis, release, uptake, and metabolism are regulated in a coordinated fashion in response to the demands placed on the system. Location is also important to function. Neuronal transporters are essential for rapid termination of the signal in neuronal-effector organ transmission,whereas non-neuronal transporters are more important for limiting the spread of the signal and for clearance of catecholamines from the bloodstream. Besides their presynaptic locations, NET and DAT are also present at several extraneuronal locations, including syncytiotrophoblasts of the placenta and endothelial cells of the lung (NET), stomach and pancreas (DAT). The extraneuronal monoamine transporter shows a broad tissue distribution, whereasthe other two non-neuronal catecholamine transporters (OCT1 and OCT2) are mainly localized to the liver, kidney, and intestine. Altered function of peripheral catecholamine transporters may be involved in disturbances of theautonomic nervous system, such as occurs in congestive heart failure and hypernoradrenergic hypertension. Peripheral catecholamine transporters provide important targets for clinical imaging of sympathetic nerves and diagnostic localization and treatment of neuroendocrine tumors, such as neuroblastomas and pheochromocytomas. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:52:28