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Titolo:
Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease
Autore:
Farin, FM; Janssen, P; Quigley, S; Abbott, D; Hassett, C; Smith-Weller, T; Franklin, GM; Swanson, PD; Longstreth, WT; Omiecinski, CJ; Checkoway, H;
Indirizzi:
Univ Washington, Dept Environm Hlth, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Environm Hlth, Seattle, WA 98195 USA Univ Washington, Dept Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Neurol, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA
Titolo Testata:
PHARMACOGENETICS
fascicolo: 8, volume: 11, anno: 2001,
pagine: 703 - 708
SICI:
0960-314X(200111)11:8<703:GPOMAS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANTIA-NIGRA; OXIDATIVE DAMAGE; RAT-BRAIN; EXPRESSION; SUSCEPTIBILITY; CANCER; LIVER; DNA; IDENTIFICATION; ASSOCIATION;
Keywords:
EPHX1; EPHX2; epoxide hydrolase; genetic polymorphisms; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Checkoway, H Univ Washington, Dept Environm Hlth, Box 357234, Seattle, WA 98195 USA Univ Washington Box 357234 Seattle WA USA 98195 WA 98195 USA
Citazione:
F.M. Farin et al., "Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease", PHARMACOGEN, 11(8), 2001, pp. 703-708

Abstract

Oxidative stress is hypothesized to play a major role in the destruction of dopaminergic neurons, which is associated with Parkinson's disease. Epoxides are potentially reactive intermediates formed through the oxidative metabolism of both exogenous and endogenous substances that contribute to cytotoxic damage mediated by oxidative stress. The microsomal (EPHX1) and soluble (EPHX2) epoxide hydrolases function to regulate the oxidation status of a wide range of xenobiotic- and lipid-derived substrates; therefore, interindividual variation in these pathways may mitigate epoxide-related cellularinjury. In this investigation, we examined the potential association between the risk of Parkinson's disease and genetic variation within the EPHX1 and EPHX2 genes. Fluorescent 5' nuclease-based assays were developed to identify the allelic status of individuals with respect to specific single nucleotide polymorphisms in exons 3 and 4 of the EPHX1 gene and exons 8 and 13 of the EPHX2 gene. EPHX1 and EPHX2 genotype data were obtained from 133 idiopathic Parkinson's disease patients and 212 control subjects matched on age, gender and ethnicity. No statistically significant differences were found in the distribution of the reference and variant alleles between Parkinson's disease and control subjects, or when results were stratified by gender. Therefore, common polymorphisms within EPHX1 and EPHX2 do not appear to be important risk factors for Parkinson's disease. Pharmacogenetics 11:703-708 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 19/01/20 alle ore 11:50:10