Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer
Autore:
Bamber, DE; Fryer, AA; Strange, RC; Elder, JB; Deakin, M; Rajagopal, R; Fawole, A; Gilissen, RAHJ; Campbell, FC; Coughtrie, MWH;
Indirizzi:
Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland Univ Dundee Dundee Scotland DD1 9SY lar Pathol, Dundee DD1 9SY, Scotland Keele Univ, N Staffordshire Hosp, Clin Biochem Res Lab, Ctr Cell & Mol Med, Stoke On Trent, Staffs, England Keele Univ Stoke On Trent Staffs England Stoke On Trent, Staffs, England Keele Univ, N Staffordshire Hosp, Dept Surg, Stoke On Trent, Staffs, England Keele Univ Stoke On Trent Staffs England Stoke On Trent, Staffs, England Univ Dundee, Ninewells Hosp & Med Sch, Dept Surg, Dundee DD1 9SY, ScotlandUniv Dundee Dundee Scotland DD1 9SY Dept Surg, Dundee DD1 9SY, Scotland
Titolo Testata:
PHARMACOGENETICS
fascicolo: 8, volume: 11, anno: 2001,
pagine: 679 - 685
SICI:
0960-314X(200111)11:8<679:PSSGIA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFOTRANSFERASE SULT1A1 POLYMORPHISM; HUMAN CYTOSOLIC SULFOTRANSFERASES; HETEROCYCLIC AMINES; GENETIC POLYMORPHISMS; METABOLIC-ACTIVATION; SULFATION; 2-AMINO-1-METHYL-6-PHENYLIMIDAZO<4,5-B>PYRIDINE; BIOLOGY;
Keywords:
colorectal cancer; sulphation; sulphotransferase; susceptibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Coughtrie, MWH Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland Univ Dundee Dundee Scotland DD1 9SY dee DD1 9SY, Scotland
Citazione:
D.E. Bamber et al., "Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer", PHARMACOGEN, 11(8), 2001, pp. 679-685

Abstract

Sulphation is an important detoxification pathway for numerous xenobiotics; however, it also plays an important role in the metabolism and bioactivation of many dietary and environmental mutagens, including heterocyclic amines implicated in the pathogenesis of colorectal and other cancers. A major sulphotransferase (SULT) enzyme in humans, SULT1A1, is polymorphic with themost common variant allele, SULT1A1*2, occurring at a frequency of about 32% in the Caucasian population. This allele codes for an allozyme with low enzyme activity and stability compared to the wild-type (SULT1A1*1) enzyme,and therefore SULT1A1 genotype may influence susceptibility to mutagenicity following exposure to heterocyclic amines and other environmental toxins. Previously, a significant association of SULT1A1*1 genotype with old age has been observed, suggesting a 'chemoprotective' role for the high-activityphenotype. Here we have compared the frequencies of the most common SULT1A1 alleles in 226 colorectal cancer patients and 293 previously described control patients. We also assessed whether SULT1A1 genotype was related to various clinical parameters in the patient group, including Duke's classification, differentiation, site, nodal involvement and survival. There was no significant difference in allele frequency between the control and cancer patient populations, nor was there a significant association with any of the clinical parameters studied. However, when the age-related difference in allele frequency was considered, a significantly reduced risk of colorectal cancer (odds ratio = 0.47; 95% confidence interval = 0.27-0.83; P = 0.009), was associated with homozygosity for SULT1A1*1 in subjects under the age of80 years. These results suggest that the high activity SULT1A1*1 allozyme protects against dietary and/or environmental chemicals involved in the pathogenesis of colorectal cancer. Pharmacogenetics 11:679 -685 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:40:59