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Titolo:
Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland
Autore:
Lan, Q; Chow, WH; Lissowska, J; Hein, DW; Buetow, K; Engel, LS; Ji, BT; Zatonski, W; Rothman, N;
Indirizzi:
NCI, Occupat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Canc Epidemiol & Genet, Bethesda, MD 20892 USA Ctr Canc, Div Canc Epidemiol & Prevent, Warsaw, Poland Ctr Canc Warsaw Poland nc, Div Canc Epidemiol & Prevent, Warsaw, Poland M Sklodowska Curie Inst Oncol, Warsaw, Poland M Sklodowska Curie Inst Oncol Warsaw Poland Inst Oncol, Warsaw, Poland Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Toxicol, Louisville, KY 40292 USA
Titolo Testata:
PHARMACOGENETICS
fascicolo: 8, volume: 11, anno: 2001,
pagine: 655 - 661
SICI:
0960-314X(200111)11:8<655:GSGASC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-POLYMORPHISM; HUMAN ERYTHROCYTES; GSTT1 GENOTYPES; ETHYLENE-OXIDE; METHYL-BROMIDE; COLON-CANCER; RISK-FACTORS; LUNG-CANCER; HUMAN BLOOD; SUSCEPTIBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lan, Q NCI, Occupat Epidemiol Branch, Div Canc Epidemiol & Genet, MSC 7240,6120 Execut Blvd,EPS 8109, Bethesda, MD 20892 USA NCI MSC 7240,6120 ExecutBlvd,EPS 8109 Bethesda MD USA 20892 92 USA
Citazione:
Q. Lan et al., "Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland", PHARMACOGEN, 11(8), 2001, pp. 655-661

Abstract

Glutathione S-transferases are important in the detoxification of a wide range of human carcinogens. Previous studies have shown inconsistent associations between the GSTT1 and GSTM1 null genotypes and stomach cancer risk. We investigated the relationship between these and related genotypes and stomach cancer risk in a population-based case-control study in Warsaw, Poland, where stomach cancer incidence and mortality rates are among the highest in Europe. DNA from blood samples was available for 304 stomach cancer patients and 427 control subjects. We observed a 1.48-fold increased risk for stomach cancer (95% confidence interval 0.97-2.25) in patients with the GSTT1 null genotype but no evidence of increased risk associated with the GSTM1, GSTM3 or GSTP1 genotypes. Furthermore, the stomach cancer risk associatedwith the GSTT1 null genotype varied by age at diagnosis, with odds ratios of 3.85, 1.91, 1.78 and 0.59 for those diagnosed at ages less than 50, 50-59, 60-69 and 70 years or older, respectively (P trend = 0.01). This was dueto a shift in the GSTT1 genotype distribution across age groups among stomach cancer patients only. These results suggest that the GSTT1 null genotype may be associated with increased risk of stomach cancer. Pharmacogenetics11:655-661 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 07/04/20 alle ore 03:47:24