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Titolo:
Research advances in ethanol metabolism
Autore:
Ramchandani, VA; Bosron, WF; Li, TK;
Indirizzi:
Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA
Titolo Testata:
PATHOLOGIE BIOLOGIE
fascicolo: 9, volume: 49, anno: 2001,
pagine: 676 - 682
SICI:
0369-8114(200111)49:9<676:RAIEM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-DEHYDROGENASE ACTIVITY; HIGH-CARBOHYDRATE MEALS; FIRST-PASS METABOLISM; RECOMMENDED NOMENCLATURE; PHARMACOKINETIC MODEL; GENDER DIFFERENCES; BODY-COMPOSITION; GENE FAMILY; ALDH GENES; HIGH-FAT;
Keywords:
alcohol dehydrogenase; aldehyde dehydrogenase; ethanol metabolism; ethnic differences; gender differences; genetic polymorphism; pharmacokinetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Ramchandani, VA Indiana Univ, Sch Med, Dept Med, 975 W Walnut St,IB 424, Indianapolis, IN 46202 USA Indiana Univ 975 W Walnut St,IB 424 Indianapolis IN USA 46202
Citazione:
V.A. Ramchandani et al., "Research advances in ethanol metabolism", PATH BIOL, 49(9), 2001, pp. 676-682

Abstract

The pharmacokinetics of alcohol determines the time course of alcohol concentration in blood after the ingestion of an alcoholic beverage and the degree of exposure of organs to its effects. The interplay between the kinetics of absorption, distribution and elimination is thus important in determining the pharmacodynamic responses to alcohol. There is a large degree of variability in alcohol absorption, distribution and metabolism, as a result of both genetic and environmental factors. The between-individual variation in alcohol metabolic rates is, in part due to allelic variants of the genesencoding the alcohol metabolizing enzymes, alcohol dehydrogenase (ADH) andaldehyde dehydrogenase (ALDH). This review summarizes recent developments in the investigation of the following influences on alcohol elimination rate: gender, body composition and lean body mass, liver volume, food and foodcomposition, ethnicity, and genetic polymorphisms in alcohol metabolizing enzymes as well as in the promoter regions of the genes for these enzymes. Evaluation of the factors regulating the rates of alcohol and acetaldehyde metabolism, both genetic and environmental, will help not only to explain the risk for development of alcoholism, but also the risk for development ofalcohol-related organ damage and developmental problems. (C) 2001 Editionsscientifiques et medicales Elsevier SAS.

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Documento generato il 08/04/20 alle ore 22:49:23