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Titolo:
Atypical and low-grade malignant vestibular schwannomas: Clinical implications of proliferative activity
Autore:
Light, JP; Roland, JT; Fishman, A; Miller, DC; Cohen, NL;
Indirizzi:
NYU, Sch Med, Dept Otolaryngol, New York, NY 10016 USA NYU New York NY USA 10016 h Med, Dept Otolaryngol, New York, NY 10016 USA NYU, Sch Med, Dept Pathol, Div Neuropathol,Kaplan Comprehens Canc Ctr, NewYork, NY 10016 USA NYU New York NY USA 10016 plan Comprehens Canc Ctr, NewYork, NY 10016 USA
Titolo Testata:
OTOLOGY & NEUROTOLOGY
fascicolo: 6, volume: 22, anno: 2001,
pagine: 922 - 927
SICI:
1531-7129(200111)22:6<922:AALMVS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLULAR SCHWANNOMA; ACOUSTIC NERVE; TRITON TUMOR; MENINGIOMAS;
Keywords:
vestibular schwannoma; malignancy; proliferation markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Roland, JT NYU, Sch Med, Dept Otolaryngol, 550 1st Ave, New York, NY 10016USA NYU 550 1st Ave New York NY USA 10016 e, New York, NY 10016 USA
Citazione:
J.P. Light et al., "Atypical and low-grade malignant vestibular schwannomas: Clinical implications of proliferative activity", OTOL NEURO, 22(6), 2001, pp. 922-927

Abstract

Objective: To examine the relationship between histopathology, immunohistochemistry, and clinical behavior in atypical and low-grade malignant vestibular schwannomas. Study Design: The study design was a retrospective case review in conjunction with a histopathologic and immunohistochemical proliferation marker study of archival specimens. Data Sources: A tertiary referral center's anatomic pathology and vestibular schwannoma computerized databases. Methods: The diagnosis of atypical or low-grade malignant vestibular schwannoma was based on the number of mitotic figures present per tumor slide. MIBI labeling indices were used to compare the proliferative activity of theatypical and low-grade malignant groups with that in an age-matched and size-matched control group. Results: Eight cases of atypical and six cases of low-grade malignant vestibular schwannoma were diagnosed from 1990 to 1998. In the atypical and low-grade malignant groups, respectively, the average patient age was 54.3 years (range, 38-74 yr) and 50 years (range, 38-72 yr), and the average total tumor size was 1.53 cm (range, 0.7-3.5 cm) and 1.55 cm (range, 1.5-2 cm). Two recurrences were identified from the low-grade malignant group, and there was one postoperative House-Brackmann Grade III facial weakness. There were no recurrences or facial palsies in the atypical group. No distant metastasis or aggressive local invasion was observed in either group. MIBI labeling indices were significantly (p less than or equal to 0.001) higher in the atypical (4.69%) and low-grade malignant (5.23%) groups than in the control group ( 1.99%). Conclusions: These findings suggest a tendency for recurrence in proliferative tumors; however, the designation of malignancy should be reconsidered. Key Words: Vestibular schwannoma-Malignancy-Prolife ration markers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:41:01