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Titolo:
Diagnosis of endolymphatic hydrops in vivo with magnetic resonance imaging
Autore:
Niyazov, DM; Andrews, JC; Strelioff, D; Sinha, S; Lufkin, R;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Div Head & Neck Surg, Ctr Hlth Sci 62 132,Dept Head & Neck Surg, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Radiol Sci, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
OTOLOGY & NEUROTOLOGY
fascicolo: 6, volume: 22, anno: 2001,
pagine: 813 - 817
SICI:
1531-7129(200111)22:6<813:DOEHIV>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNER-EAR FLUIDS; GUINEA-PIG; TEMPORAL BONE; MR; PERILYMPH; RAT; MICROSCOPY; GENTAMICIN; TISSUES; COCHLEA;
Keywords:
endolymphatic hydrops; Meniere's disease; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Niyazov, DM Univ Calif Los Angeles, Sch Med, Div Head & Neck Surg, Ctr Hlth Sci 62 132,Dept Head & Neck Surg, 10833 Le Conte Ave, Los Angeles, CA 90095 USA Univ Calif Los Angeles 10833 Le Conte Ave Los Angeles CA USA 90095
Citazione:
D.M. Niyazov et al., "Diagnosis of endolymphatic hydrops in vivo with magnetic resonance imaging", OTOL NEURO, 22(6), 2001, pp. 813-817

Abstract

Hypothesis: High-resolution magnetic resonance imaging (MRI) at 1.5 T preferentially enhances the perilymph over endolymph after administration of contrast with gadodiamide, which allows for differentiation of the membranouslabyrinth. Furthermore, this imaging allows for the detection of endolymphatic hydrops. Background: Endolymphatic hydrops is believed to be associated with a number of ear diseases, including Meniere's disease. Although the pathologic changes of overaccumulation of endolymph in the inner ear are obvious on postmortem histologic examination of the temporal bone, they have yet to be observed in a living organism. Previous attempts to visualize this condition with high-resolution contrast-enhanced computed tomographic imaging and MRI have been unsuccessful. Methods: Healthy pigmented guinea pigs underwent a unilateral surgical ablation of the endolymphatic sac to create endolymphatic hydrops in the ear. High-resolution temporal bone imaging was performed by use of a 1.5-T MRI system. Two-dimensional images were acquired by a spin-echo technique with and without contrast enhancement by gadodiamide. Results: T1-weighted gadodiamide contrast-enhanced MRI of the midmodiolar level of the cochlea demonstrated that the perilymph appeared to be preferentially enhanced relative to the endolymph, resulting in a clear distinction between the scalae of the inner ear. The contrast-enhanced T1-weighted MRI of the midmodiolar level of the hydropic cochlea demonstrated a significantly enlarged scala media in comparison with the normal cochlea in the sameanimal. Conclusion: The demonstration of endolymphatic hydrops has been possible for the first time in vivo by the use of a standard 1.5-T MRI system. This research has important clinical implications: Specifically. this technique may allow for the noninvasive diagnosis of Meniere's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:03:23