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Titolo:
Macrophages and possible osteoclast differentiation in the rat bullar boneduring experimental acute otitis media, with reference to tympanosclerosis
Autore:
Flodin, MF;
Indirizzi:
Karolinska Hosp, Karolinska Inst, Dept Otorhinolaryngol, Stockholm, SwedenKarolinska Hosp Stockholm Sweden pt Otorhinolaryngol, Stockholm, Sweden
Titolo Testata:
OTOLOGY & NEUROTOLOGY
fascicolo: 6, volume: 22, anno: 2001,
pagine: 771 - 775
SICI:
1531-7129(200111)22:6<771:MAPODI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; MIDDLE-EAR; MYRINGOSCLEROSIS; INHIBITION;
Keywords:
immunohistochemistry; macrophages; otitis media; osteoclasts; rat; tympanosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Flodin, MF Karolinska Inst, Dept Plast & Reconstruct Surg, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 76 Stockholm, Sweden
Citazione:
M.F. Flodin, "Macrophages and possible osteoclast differentiation in the rat bullar boneduring experimental acute otitis media, with reference to tympanosclerosis", OTOL NEURO, 22(6), 2001, pp. 771-775

Abstract

Hypothesis: Large osteoclast-like cells, labeled by using monoclonal antibodies directed against macrophages, are participating in a bone remodeling process in the rat bullar bone after induced experimental acute otitis media, leading to tympanosclerosis. Background: In humans, tympanosclerosis is a sequale of chronic otitis media. It causes hearing disability, especially if the ossicles or the inner ear are affected. No successful treat-ment is available. To evaluate the inflammatory stages that may lead to tympanosclerosis, the current study was performed. Methods: Sprague-Dawley rats were exposed to a pneumococcus Type 3 solution into the middle ear. The rats were killed at 3, 6, and 10 days after inoculation. Sections from the ear specimen were stained immunohistochemically. Antibodies used were directed against macrophages. Results: Positive cells were seen in the tympanic membrane, in the middle ear mucosa, and close to the tympanic membrane insertion into the bone, Macrophages appeared to be linearized adjacent to the bullar bone, both on theinner and on the outer bullar wall. These cells had the appearance of osteoclasts. Conclusion: A differentiation of macrophages to osteoclasts is possible during induced otitis media in the rat, initiating a bone-remodeling process leading to tympanosclerosis.

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Documento generato il 20/02/20 alle ore 00:24:23