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Titolo:
Adjuvant radio-chemotherapy in stage II-III rectal cancer with 24-hour infusion of high-dose 5-fluorouracil and folinic acid: Evaluation of feasibility
Autore:
Dencausse, Y; Sturm, J; Hartung, G; Diezler, P; Edler, L; Bambach, M; Wojatschek, C; Lindemann, H; Queisser, W;
Indirizzi:
Univ Heidelberg, Klinikum Mannheim, Onkol Zentrum, Med Klin 3, D-68167 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68167 in 3, D-68167 Mannheim, Germany Univ Heidelberg, Klinikum Mannheim, Inst Radiol, D-68167 Mannheim, GermanyUniv Heidelberg Mannheim Germany D-68167 diol, D-68167 Mannheim, Germany Univ Heidelberg, Klinikum Mannheim, Chirurg Klin, D-68167 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68167 Klin, D-68167 Mannheim, Germany Deutsch Krebsforschungszentrum, D-6900 Heidelberg, Germany Deutsch Krebsforschungszentrum Heidelberg Germany D-6900 elberg, Germany St Marien Hosp, Hagen, Germany St Marien Hosp Hagen GermanySt Marien Hosp, Hagen, Germany
Titolo Testata:
ONKOLOGIE
fascicolo: 5, volume: 24, anno: 2001,
pagine: 476 - 480
SICI:
0378-584X(200110)24:5<476:ARISIR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED COLORECTAL-CANCER; RADIATION-THERAPY; RANDOMIZED TRIAL; FLUOROURACIL; LEUCOVORIN; CARCINOMA; RADIOCHEMOTHERAPY; BOLUS;
Keywords:
rectal cancer; adjuvant radio-chemotherapy; 24-hour infusion; 5-fluorouracil; folinic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dencausse, Y Univ Heidelberg, Klinikum Mannheim, Onkol Zentrum, Med Klin 3, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany Univ Heidelberg Theodor Kutzer Ufer 1-3 Mannheim Germany D-68167
Citazione:
Y. Dencausse et al., "Adjuvant radio-chemotherapy in stage II-III rectal cancer with 24-hour infusion of high-dose 5-fluorouracil and folinic acid: Evaluation of feasibility", ONKOLOGIE, 24(5), 2001, pp. 476-480

Abstract

Background. Postoperative radio-chemotherapy has been established as standard treatment for stage II and III rectal cancer patients in the last decade. To improve the efficacy of this therapy, we decided to evaluate continuous 24-hour infusion of 5-fluorouracil (5-FU) with folinic acid (FA) in combination with local radiation versus standard bolus 5-FU/FA with local radiation in a randomized study. Here we report on the first 28 patients to receive the experimental treatment. Patients and Methods: Patients with stage II and III rectal cancer received weekly 2-hour infusions of FA 500 mg/m(2) followed by continuous 24-hour infusions of 5-FU 2,600 mg/m(2) postoperatively via a Port-A-Cath system. The first cycle included 8 consecutive weeklyadministrations, the 1st-4th in full dose, the 5th-8th with 50% reduced dose while local irradiation (45 or 50.4 Gy) was performed. Thereafter, two further chemotherapy cycles (6 weekly administrations, 100% dose) followed. Results: 28 patients received continuous 5-FU/FA treatment, of whom only 21were evaluable for tolerability. 19 patients (90.4%) completed the first cycle, only 14 patients entered the second treatment cycle. Especially during the combined radiochemotherapy, increased toxicity was observed with grade III/IV diarrhea (n = 2), nausea (n = 1), leukopenia (n = 1), and cardiac toxicity (n = 1). Conclusion: The high rate of premature treatment dropout indicate that the chosen schedule of weekly high-dose 5-FU/FA continuous infusion and combined postoperative radiotherapy should not be recommended for further use in postoperative adjuvant treatment.

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Documento generato il 22/01/20 alle ore 21:38:58