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Titolo:
Cell transformation by the middle T-antigen of polyoma virus
Autore:
Ichaso, N; Dilworth, SM;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Dept Metab Med, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
ONCOGENE
fascicolo: 54, volume: 20, anno: 2001,
pagine: 7908 - 7916
SICI:
0950-9232(20011126)20:54<7908:CTBTMT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN PHOSPHATASE 2A; PHOSPHATIDYLINOSITOL KINASE-ACTIVITY; MEDIUM TUMOR-ANTIGEN; SIGNAL-TRANSDUCTION; TYROSINE PHOSPHORYLATION; COMPLEX-FORMATION; NEOPLASTIC TRANSFORMATION; ONCOGENIC TRANSFORMATION; MONOCLONAL-ANTIBODIES; SH2 DOMAINS;
Keywords:
middle T-antigen; cell transformation; signalling pathways; tyrosine kinases; PP2A;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Dilworth, SM Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Dept Metab Med, Du Cane Rd, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med Du Cane Rd London England W12 0NN
Citazione:
N. Ichaso e S.M. Dilworth, "Cell transformation by the middle T-antigen of polyoma virus", ONCOGENE, 20(54), 2001, pp. 7908-7916

Abstract

The polyoma virus region expressed early in the lytic cycle encodes three proteins, or T-antigens, that together cause the infected cell to enter thecell cycle and so provide a suitable cellular environment for replication of the viral genome. Under some circumstances infection does not kill the cell, but the T-antigens are still produced, resulting in the cell becoming transformed and tumorigenic. Most of this transforming action is exerted bythe middle T-antigen, which has the ability to convert established cell lines to an oncogenic state. Middle T is a membrane bound polypeptide that interacts with a number of the proteins used by tyrosine kinase associated receptors to stimulate mitogenesis, so MT can be considered as a permanently active analogue of a receptor. Through a defined series of interactions, MTassembles a large multi-protein complex at the cell membrane, consisting of MT, the core dimer of protein phosphatase 2A, an si-c-family tyrosine kinase, and via phosphotyrosines, ShcA, phosphatidylinositol (3') kinase, and phospholipase C gamma -1. Tyrosine phosphorylation stimulates PI3K and PLC gamma -1 enzymatic activity, and on ShcA creates binding sites for Grb2 with its associated Sos1 and Gab1. This activates p21(ras), and hence, the MAPkinase cascade. Consequently, MT can be used as a model for studying cell transformation and growth factor receptor signalling pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:44:13