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Titolo:
Ester-modified (TcO)-Tc-99m[SN(R)S/S] mixed ligand complexes: synthesis and preliminary evaluation
Autore:
Tsoukalas, C; Pirmettis, I; Patsis, G; Papadopoulos, A; Raptopoulou, CP; Terzis, A; Papadopoulos, M; Chiotellis, E;
Indirizzi:
Demokritos Natl Ctr Sci Res, Inst Radioisotopes Radiodiagnost Prod, GR-15310 Athens, Greece Demokritos Natl Ctr Sci Res Athens Greece GR-15310 -15310 Athens, Greece Demokritos Natl Ctr Sci Res, Inst Mat Sci, GR-15310 Athens, Greece Demokritos Natl Ctr Sci Res Athens Greece GR-15310 -15310 Athens, Greece
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 8, volume: 28, anno: 2001,
pagine: 975 - 982
SICI:
0969-8051(200111)28:8<975:E(MLCS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMAGING AGENTS; OXOTECHNETIUM(V) COMPLEXES; TECHNETIUM-99M L,L-ECD; CYSTEINATE DIMER; IN-VIVO; BRAIN; SPECT; BIODISTRIBUTION; OXORHENIUM; AFFINITY;
Keywords:
technetium; rhenium; brain imaging; mixed ligand complexes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Chiotellis, E Demokritos Natl Ctr Sci Res, Inst Radioisotopes Radiodiagnost Prod, GR-15310 Athens, Greece Demokritos Natl Ctr Sci Res Athens GreeceGR-15310 Greece
Citazione:
C. Tsoukalas et al., "Ester-modified (TcO)-Tc-99m[SN(R)S/S] mixed ligand complexes: synthesis and preliminary evaluation", NUCL MED BI, 28(8), 2001, pp. 975-982

Abstract

Two novel Tc-99m-(SNS/S) complexes: a mono-ester compound carrying an ethyl ester group on the tridentate ligand, (TcO)-Tc-99m[C2H5OOCCH2N(CH2CH2S)(2)][SC6H4CH3], 3, and a diester compound, carrying a second ethyl ester group on the monodentate ligand, (TcO)-Tc-99m[C2H5OOCCH2N(CH2CH2S)(2)][SC6H4COOC2H5], 4, were synthesized. The corresponding oxorhenium(V) complexes, 1 and 2 were also synthesized. Enzymatic hydrolysis demonstrated that 3 remainsintact after 10 min incubation while 4 is totally converted to an unidentified hydrophilic complex. Tissue distribution data in mice revealed that both complexes, 3 and 4, exhibit significant initial brain uptake (1.42 and 1.01% of injected dose at 5 minutes post injection respectively) and fast blood clearance. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:00:28