Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
In vivo evaluation of an In-111-labeled ST-peptide analog for specific-targeting of human colon cancers
Autore:
Gali, H; Sieckman, GL; Hoffman, TJ; Owen, NK; Chin, DT; Forte, LR; Volkert, WA;
Indirizzi:
Univ Missouri, Dept Radiol, Columbia, MO 65211 USA Univ Missouri ColumbiaMO USA 65211 , Dept Radiol, Columbia, MO 65211 USA Univ Missouri, Dept Biochem, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Biochem, Columbia, MO 65211 USA Univ Missouri, Dept Pharmacol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ept Pharmacol, Columbia, MO 65211 USA Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Internal Med, Columbia, MO 65211 USA Harry S Truman Mem Vet Adm Med Ctr, Res Serv, Columbia, MO 65201 USA HarryS Truman Mem Vet Adm Med Ctr Columbia MO USA 65201 ia, MO 65201 USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 8, volume: 28, anno: 2001,
pagine: 903 - 909
SICI:
0969-8051(200111)28:8<903:IVEOAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL GUANYLATE-CYCLASE; HEAT-STABLE ENTEROTOXIN; RADIONUCLIDE THERAPY; SOMATOSTATIN ANALOG; COLORECTAL TUMORS; CYCLIC-GMP; RECEPTORS; RADIOPHARMACEUTICALS; ANTIBODY; BIODISTRIBUTION;
Keywords:
colorectal cancer; guanylin; ST-peptide; GC-C receptors; In-111; DOTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Volkert, WA Univ Missouri, Dept Radiol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 l, Columbia, MO 65211 USA
Citazione:
H. Gali et al., "In vivo evaluation of an In-111-labeled ST-peptide analog for specific-targeting of human colon cancers", NUCL MED BI, 28(8), 2001, pp. 903-909

Abstract

In vitro competitive binding studies of In-DOTA-NCS-6-Ahx-Phe(19)-ST[1-19]vs. I-125-Tyr(5)-6-Ahx-Phe(19)-ST[1-19] with guanylate cyclase -C (GC-C) receptors on human colon cancer LS-180 cells revealed an IC50 value of 7.7 +/-0.1.6 nM. The in vitro cellular residualization studies of the In-111-DOTA-NCS-ST peptide and GC-C receptor mediated stimulated cGMP production withLS-180 cells demonstrates that this peptide selectively binds to LS-180 cells in an agonistic fashion. In vivo biodistribution studies in LS-180 tumor bearing SCID mice demonstrates that the In-111-DOTA-NCS-ST peptide targets the tumor with a specific uptake of 0.94 +/-0.31%ID/g at 1 hr p.i. and approximately 23% was retained by the tumor at 4 hrs p.i. The radioactivity cleared rapidly from the blood stream with 84.5 +/-3.4%ID at 1h p.i. found in the urine. High activity in urine and kidney, and minimal activity in liver and intestines, demonstrates preferential clearance of the radioactivitythrough the renal/urinary pathway. The specific in vitro and in vivo accumulation of the radioactivity by LS-180 human colonic cancer cells highlights the potential of radiometallated-DOTA-ST analogs as diagnostic/therapeutic radiopharmaceuticals. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:53:20