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Titolo:
Developmental lead exposure: behavioral alterations in the short and long term
Autore:
Moreira, EG; Vassilieff, I; Vassilieff, VS;
Indirizzi:
Univ Estadual Paulista, Ctr Toxicol Assistance, BR-18618000 Botucatu, SP, Brazil Univ Estadual Paulista Botucatu SP Brazil BR-18618000 BCucatu, SP, Brazil
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 5, volume: 23, anno: 2001,
pagine: 489 - 495
SICI:
0892-0362(200109/10)23:5<489:DLEBAI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; LOCOMOTOR-ACTIVITY; RAT HIPPOCAMPUS; OPEN-FIELD; RECEPTORS; ANXIETY; NEUROTOXICITY; POTENTIATION; STRIATUM; TOXICITY;
Keywords:
lead; developmental lead exposure; lead toxicity; blood lead; brain lead;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Vassilieff, I Univ Estadual Paulista, Ctr Toxicol Assistance, BR-18618000 Botucatu, SP, Brazil Univ Estadual Paulista Botucatu SP Brazil BR-18618000BCzil
Citazione:
E.G. Moreira et al., "Developmental lead exposure: behavioral alterations in the short and long term", NEUROTOX T, 23(5), 2001, pp. 489-495

Abstract

Wistar dams were exposed to 500 ppm of Pb, as Ph acetate, or 660 ppm Na acetate in drinking water during pregnancy and lactation. Male pups at 23 (weaned) or 70 days (adult) of age were submitted to behavioral evaluation andPb determination. The behaviors evaluated were: locomotor activity (open-field test), motor coordination (rotarod test), exploratory behavior (holeboard test), anxiety (elevated plus maze and social interaction tests), and learning and memory (shuttle box). Ph levels were measured in the blood and cerebral regions (hippocampus and striatum) of dams and pups. The results of the present report demonstrated that exposure to Ph during pregnancy and lactation induces in weaned pups hyperactivity, decreased exploratory behavior, and impairment of learning and memory. These alterations were observedat blood Ph levels in the range that may be attained in children chronically exposed to low levels of Pb (21 +/- 3 mug/dl). Regarding adults, the results demonstrated that the regimen of exposure adopted induces anxiety in these animals at nondetectable blood Ph levels. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 25/01/20 alle ore 00:15:40