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Titolo:
Differential contributions of NMDA and non-NMDA receptors to spinal Fos expression evoked by superficial tissue and muscle inflammation in the rat
Autore:
Hu, JY; Zhao, ZQ;
Indirizzi:
Fudan Univ, Inst Neurobiol, Shanghai 200433, Peoples R China Fudan Univ Shanghai Peoples R China 200433 nghai 200433, Peoples R China Chinese Acad Sci, Shanghai Inst Physiol, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 106, anno: 2001,
pagine: 823 - 831
SICI:
0306-4522(2001)106:4<823:DCONAN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; PRIMARY AFFERENT-FIBERS; GASTROCNEMIUS-SOLEUS MUSCLE; AMINO-ACID RECEPTORS; GENE-RELATED PEPTIDE; DORSAL HORN; GLUTAMATE RECEPTORS; HORSERADISH-PEROXIDASE; SUBSTANCE-P; TRANSGANGLIONIC TRANSPORT;
Keywords:
inflammation; DL-2-amino-5-phosphonovaleric acid; 6,7-dinitroquinoxaline-2,3-dione; Fos; spinal dorsal horn;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, ZQ Fudan Univ, Inst Neurobiol, 220 Han Dan Rd, Shanghai 200433, Peoples R China Fudan Univ 220 Han Dan Rd Shanghai Peoples R China 200433 China
Citazione:
J.Y. Hu e Z.Q. Zhao, "Differential contributions of NMDA and non-NMDA receptors to spinal Fos expression evoked by superficial tissue and muscle inflammation in the rat", NEUROSCIENC, 106(4), 2001, pp. 823-831

Abstract

The role of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the spinal cord in the transmission of nociceptive afferents from superficial tissue and muscle was studied by examining the effects of NMDA or non-NMDA receptor antagonists on Fos expression in the spinal dorsal hom. Muscle inflammation was induced by injection of turpentine oil into the gastrocnemius muscle, whereas superficial tissue inflammation was induced by an intraplantar injection of turpentine oil into the hindpaw. The NMDA receptor antagonist DL-2-amino-5-phosphonovaleric acid (AP-5), the non-NMDA receptor antagonist6,7-dinitroquinoxaline-2,3-dione (DNQX) or normal saline were intrathecally administered 15 min before an intramuscular or intraplantar injection of turpentine oil. Muscle inflammation evoked expression of Fos-Eke immunoreactive neurons staining in neurons that were predominantly distributed in themiddle portions of laminae I-IIouter and the lateral portions of laminae V-VI of the ipsilateral dorsal horn at the spinal L-4-L-5. DNQX, but not AP-5, significantly reduced the total number of Fos-Eke immunoreactive neuronsevoked by muscle inflammation. In contrast, superficial tissue inflammation evoked expression of Fos-like immunoreactive neurons in the medial portions of laminae and V-VI of the ipsilateral dorsal horn at the spinal L4-L5 that was blocked by AP-5, but not by DNQX. Injection of normal saline did not influence the numbers of Fos-LI neurons. These results indicate that different glutamate receptors in the dorsal horn of the spinal cord may mediate nociceptive input from superficial tissue(particularly skin) and muscle. DNQX receptors may mediate transmission ofnociceptive information originating in muscle, while NMDA receptors may preferentially mediate transmission of nociceptive information originating inskin. (C) 2001 Published by Elsevier Science Ltd on behalf of IBRO.

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Documento generato il 01/04/20 alle ore 18:54:31